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. 2017 Jan 6;12(1):e0169331. doi: 10.1371/journal.pone.0169331

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© 2017 Ceulemans et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 4 — A-C OCA preserves the intestinal mucosal wall integrity in intestinal IRI as shown by (A) Park-Chiu score; (B) villus-length; and (C) representative histological illustration for each group, Hematoxylin and Eosin staining, magnification: X200. OCA: obeticholic acid; TEER: trans-epithelial electrical resistance; FD20: fluorescein isothiocyanate-labelled dextran 20 kiloDalton; IRI: ischemia reperfusion injury; *: p<0.05; **: p<0.01; ***: p<0.001. D-F The protective effect of OCA on intestinal wall permeability is reflected by (D) its amelioration of TEER, (E) prevention of FD20 leakage; and (F) prevention of endotoxin translocation after intestinal IRI. OCA: obeticholic acid; TEER: trans-epithelial electrical resistance; FD20: fluorescein isothiocyanate-labelled dextran 20 kiloDalton; IRI: ischemia reperfusion injury; *: p<0.05; **: p<0.01; ***: p<0.001.