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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Oral Oncol. 2016 Dec 8;64:65–72. doi: 10.1016/j.oraloncology.2016.11.017

Figure 2. Comparing biomarker expression between the first and last passages of each PDX.

Figure 2

Depiction of the protein expression (DAB MOD value) of EGFR, pEGFR, pAkt, pERK and ERCC1 for the first and last passages of each PDX (DAB MOD: 3,3′-diaminobenzidine mean optical density). The mean difference and 95% confidence intervals (CI) are presented for the comparisons between the first and last passages of each PDX by biomarker (**P<0.01). Tissue data was used for all biomarkers except ERCC1, where the nuclear fraction was solely utilized (nuclear DAB MOD values).