Table 1.
Patient and tumor characteristics and their influence on PDX establishment.
| Characteristica | Category | PDX did not develop | PDX established | P-valueb |
|---|---|---|---|---|
| Age at diagnosis (yrs) | <60 | 2 (15.4%) | 11 (84.6%) | 0.682 |
| >60 | 5 (23.8%) | 16 (76.2%) | ||
| Gender | Female | 2 (20.0%) | 8 (80.0%) | 1.000 |
| Male | 5 (20.8%) | 19 (79.2%) | ||
| Alcohol use (drinks/week) | Occasional (0–6) | 2 (13.3%) | 13 (86.7%) | 0.366 |
| Moderate (7–20) | 1 (12.5%) | 7 (87.5%) | ||
| Heavy (>20) | 4 (36.4%) | 7 (63.6%) | ||
| Tobacco use (pack-years) | 0–19 | 1 (7.1%) | 13 (92.9%) | 0.364 |
| 20 or greater | 5 (25.0%) | 15 (75.0%) | ||
| T Stage | T1 | 2 (25.0%) | 6 (75.0%) | 0.735 |
| T2 | 3 (30.0%) | 7 (70.0%) | ||
| T3 | 0 (0.0%) | 4 (100.0%) | ||
| T4 | 2 (16.7%) | 10 (83.3%) | ||
| Nodal status | Negative | 3 (23.1%) | 10 (76.9%) | 1.000 |
| Positive | 4 (19.0%) | 17 (81.0%) | ||
| Differentiation | Well | 3 (21.4%) | 11 (78.6%) | 1.000 |
| Moderate | 3 (20.0%) | 12 (80.0%) | ||
| Poor | 1 (20.0%) | 4 (80.0%) | ||
| HPV status (p16 IHC) | Negative | 5 (20.8%) | 19 (79.2%) | >0.999 |
| Positive | 2 (20.0%) | 8 (80.0%) | ||
| Anatomic site | Non-oropharynx | 4 (17.4%) | 19 (82.6%) | 0.656 |
| Oropharynx | 3 (27.3%) | 8 (72.7%) |
a
N (%) for categorical variables (all other characteristics).
b
P-values obtained via Fisher’s Exact test.