Extended Data Figure 2. XRCC1 and Lig3a protein levels in XRCC1^-/- RPE-1 cells and XRCC1 patient cells.

Quantification of XRCC1 (a) and Lig3α (b) protein levels in the indicated cell lines by Western blotting. Data are the mean signal intensity from three independent experiments (+/-SEM) normalized to tubulin and to the respective wild type (WT) sample for each cell type. The anti-XRCC1 signal detected in XRCC1^-/- RPE-1 cells reflects non-specific background.