Fig. 3.

IL37tg mice have enhanced sleep responses to influenza virus challenge on post infection (PI) day 6.IL37tg mice (n=10) had more NREMS [A] during light and/or dark hours (shaded areas representing the 12 h dark period) than WT mice (n=12) and their own baseline values. Both strains manifest an increased number of NREMS episodes [D] during the dark period following viral challenge. REMS amounts [B] during the dark and REMS bout frequency [E] during the light and dark were inhibited in WT mice, but not IL37tg mice after infection. There were no changes in NREMS EEG SWA in on PI day 6 in either strain regardless of the photoperiod [C]. Power spectra [F] decreased with infection in WT mice but not IL37tg mice (PI day 6 ZT0-12 shown; *p<0.05, **p<0.01, ***p<0.001, WT baseline vs. PI day 6; +p<0.05, IL37tg baseline vs. PI day 6 and #p<0.05, WT vs. IL37tg; statistical symbols derived from 12 h data analyses; all data expressed as mean ± SEM).