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. Author manuscript; available in PMC: 2017 Dec 1.
Published in final edited form as: Cell Stem Cell. 2016 Dec 1;19(6):690–702. doi: 10.1016/j.stem.2016.11.014

Figure 1. Zika virus genome and its encoded proteins.

Figure 1

(A) A diagram of a flavivirus genomic RNA, which is approximately 11kb in length and encodes a single open reading frame. Both 5’ and 3’ end of the genome contain non-translated, structured RNA sequences that are important for replication. (B) Processing strategy and protein products. The polyprotein is processed at various sites by host (red arrow heads) and viral (down black arrows) proteases. The protease responsible for cleaving the NS1/2A junction remains unknown at this time. The membrane topology and function of key ZIKV proteins are also illustrated. The topological arrangement of the structural proteins allows the lipid bilayer to wrap around the nucleocapsid structure and display the envelope proteins on the outer surface of the viral membrane. NS1 is a lumenal protein that functions during replication and can also be secreted to the outside of the cell to act as a pathogenesis factor.