Table 1.
Structures and potencies of inhibitors tested on rabbit liver sEH.
| Name, synonym | Structure | Rabbit IC50 nM | Mass (Da) |
|---|---|---|---|
| t-TUCB UC1728 |
|
2 | 438.3 |
| TUPS UC1709 |
|
88 | 381.4 |
| TPPU UC1770 |
|
275 | 359.3 |
t-TUCB or UC1728 (trans-4-{4-[3-(4-Trifluoromethoxy-phenyl)-ureido]-cyclohexyloxy}-benzoic acid, TUPS or UC1709 (trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea), TPPU or UC1770 (1-methylsulfonyl-piperidin-4-yl)-3-(4-trifluoromethoxy-phenyl)-urea).