Table 1.
Under- and over-expressed genes after E2 treatment in CSC-enriched female and male TC samples.
| Male | Female | |
|---|---|---|
| Estrogen Receptors | ↑ERB | ↑ERA |
| Growth Factors | ↑FGFR2 | ↑EGF |
| ↑FGFR2 | ||
| Cancer Stem Cell Markers | ↑ABCG2 | ↑ABCB5 |
| ↑ALDH1A1 | ||
| ↑GATA3 | ||
| ↑ITGA6 | ||
| Loss of Stemness | ↓DACH1 | |
| ↓PECAM | ||
| Pluripotency | ↑NANOG | |
| ↑OCT3 | ||
| ↑SOX2 | ||
| Self-Renewal | ↓HEDGEHOG | ↑HEDGEHOG |
| ↑HIPPO | ||
| ↑NOTCH | ||
| ↑WNT | ||
| Cell-Cycle | ↑WEE1 | ↑AURKA |
| ↑CCND3 | ||
| ↑CDC20 | ||
| ↑MKI67 | ||
| ↑SKP2 | ||
| ↑STMN1 | ||
| ↓WEE1 | ||
| Angiogenesis | ↑VEGFR2 | ↓ANGPT1 |
| ↓ANGPT2 | ||
| ↑SERPINF1 | ||
| ↓VEGFR1 | ||
| ↓VEGFR2 | ||
| Epithelial-Mesenchymal Transition | ↓KLF17 | ↑KLF17 |
| ↑SNAI1 | ↑OCLN | |
| ↓SNAI1 | ||
| ↓TWIST1 | ||
| ↓TWIST2 |