. Author manuscript; available in PMC: 2017 Jan 6.

Published in final edited form as: Early Interv Psychiatry. 2013 May 22;7(4):345–360. doi: 10.1111/eip.12054

Table 4.

FHR studies examining neuroimaging markers.

Study (ref)	Cohort	Population	Model variables of interest	Outcome of interest	Results Reported
Study (ref)	Cohort	Population	Model variables of interest	Outcome of interest	Sensitivity		Specificity	PPV	NPV
43	EHRS	A –65 HR subjects B –18 HR subjects with transient or partial psychotic symptoms	Grey matter changes in R cerebellum, L uncus, L inferior temporal gyrus	HR subjects developing schizophrenia versus those remaining well	A	0.13– 0.38	0.88–0.96	0.20– 0.60	0.88– 0.92
43	EHRS				B	0.38– 0.63	0.70–0.80	0.50– 0.71	0.58– 0.73
44	EHRS	21 control subjects, 41 HR without psychotic symptoms, 21 HR with psychotic symptoms (4 HR subsequently ill)	fMRI parietal lobe activation, anterior cingulate deactivation, reduced right lingual gyrus and temporal activation	HR subjects developing schizophrenia versus those remaining well	ROIs	-	-	0.17– 0.80	0.98– 1.00
44	EHRS				DFA	-	-	0.50– 0.60	0.95– 0.98

Cohorts: EHRS, Edinburgh High Risk Study. ROIs, regions of interest. DFA, discriminant function analysis. Model variables of interest include variables that were ultimately nonsignificant; readers are encouraged to refer to the text or the original article for additional information.