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. Author manuscript; available in PMC: 2018 Jan 6.
Published in final edited form as: Circ Res. 2016 Oct 11;120(1):110–119. doi: 10.1161/CIRCRESAHA.116.309977

Figure 2. SPEG is downregulated in human heart failure and a mouse model of cardiac myocyte specific inducible Speg knockout.

Figure 2

(A) Quantitative real-time PCR analysis of SPEG mRNA transcript abundance in myocardium from patients suffering from HF or patients with normal heart function (NF). (B) SPEG western blots in hearts from inducible cardiac-specific SPEG-deficient mice (MCM-Spegfl/fl) and MCM-control mice, and (C) Quantification of SPEG levels in MCM and MCM-Spegfl/fl knockout mice. n, number of hearts, mice. * P<0.05, ***P<0.001.