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. Author manuscript; available in PMC: 2018 Jan 6.
Published in final edited form as: Circ Res. 2016 Oct 11;120(1):110–119. doi: 10.1161/CIRCRESAHA.116.309977

Figure 7. Loss of TTs and JPH2 phosphorylation precedes heart failure in MCM-Spegfl/fl mice.

Figure 7

(A–B) Representative images of ventricular myocytes isolated from MCM-Spegfl/fl mice or MCM controls 2 weeks post tamoxifen stained with di-8-ANEPPS and zoom (C–D) showing TT structure. (E) Quantification of TT Power. (F) Representative blot of total JPH2 with GAPDH as loading control from mouse heart lysates 2 weeks post tamoxifen and (G) corresponding quantification. (H) Representative image of JPH2 phosphoserine (pSer) Western blot normalized to JPH2 from immunoprecipitates from mice 2 weeks post tamoxifen and (I) quantification of phosphoserine normalized to total JPH2. Number in bars = number cells (mice); number hearts. * P<0.05.