TABLE 2.
Differences in the pharmacokinetic parameters of ertapenem by sex
| Parameter | Ratio of point estimates for male volunteers/female volunteers (90% CIa) | P value for differences by sexb |
|---|---|---|
| Cmax (mg/liter) | 97 (84-111) | 0.661 |
| AUC dose (mg · h/l) | 81 (72-90) | 0.004 |
| CLtot (ml/min) | 124 (11-138) | 0.004 |
| CLR (ml/min) | 151 (112-205) | 0.030 |
| CLNR (ml/min) | 108 (73-160) | 0.736 |
| t1/2 | 88 (78-100) | 0.095 |
| MRT (h) | 82 (74-91) | 0.003 |
| Vss (liter) | 101 (87-118) | 0.884 |
| Vz (liter) | 109 (89-113) | 0.461 |
| Cmin (mg/liter) | 54 (37-79) | 0.017 |
| fu (%) | 126 (93-170) | 0.195 |
a
CI, confidence interval.
b
Boldface indicates a statistically significant difference.