Table 1.
Associations between TLR4 variant rs1927907 and inflammatory mediators induced by ex vivo stimulation of blood from 300 healthy subjects with S. aureus
| Median (IQR) in pg/ml | ||||||
|---|---|---|---|---|---|---|
| IL-6 | IL-8 | TNF-α | IL-1β | G-CSF | ||
| rs1927907 | ||||||
| Genotype | ||||||
| CC | 1480 (861–2656) | 4532 (3090–7610) | 927 (574–1433) | 763 (463–1328) | 55 (34–99) | |
| CT | 1852 (1304–4117) | 5687 (3990–10956) | 1128 (726–2684) | 1100 (699–1727) | 82 (49–148) | |
| TT | 3096 (701–5492) | 7658 (2772–12544) | 1833 (219–3447) | 2243 (599–3886) | 99 (27–170) | |
| P valuea | 0.012 | 0.065 | 0.017 | 0.002 | 0.001 | |
a
Linear regression model on log transformed cytokine concentrations assuming an additive genetic model and adjusting for monocyte count.