Table 2. Univariate analysis for recurrence of HCC.
Preoperative variable [n] | P | Incidence of recurrence (%) | ||
---|---|---|---|---|
1 year | 3 years | 5 years | ||
Age, years | 0.292 | |||
≤60 [393] | 10.3 | 14.7 | 16.9 | |
>60 years [68] | 8.9 | 10.4 | 13.1 | |
Gender | 0.320 | |||
Male [395] | 10.5 | 15.4 | 17.7 | |
Female [66] | 6.1 | 10.0 | 15.2 | |
Hepatitis B virus | 0.159 | |||
Positive [394] | 10.8 | 14.9 | 17.2 | |
Negative [67] | 4.5 | 10.2 | 11.9 | |
Milan criteria | 0.000 | |||
Within [305] | 6.6 | 5.3 | 7.3 | |
Exceeding [156] | 20.6 | 30.4 | 33.8 | |
UCSF criteria | 0.000 | |||
Within [349] | 5.2 | 7.6 | 9.8 | |
Exceeding [112] | 24.3 | 34.2 | 35.3 | |
Asan criteria | 0.000 | |||
Within [398] | 7.4 | 10.0 | 11.9 | |
Exceeding [63] | 19.0 | 39.7 | 45.1 | |
Tumor size, cm | 0.000 | |||
≤3 [304] | 5.0 | 7.0 | 8.3 | |
>3, ≤5 [127] | 17.4 | 24.6 | 29.6 | |
>5 [30] | 26.7 | 40.0 | 45.0 | |
No. of tumors | 0.000 | |||
<3 [320] | 7.2 | 9.8 | 11.8 | |
≥3 [141] | 15.9 | 24.0 | 26.8 | |
PIVKAII (maul/mol) | 0.000 | |||
≤100 [389] | 7.0 | 10.7 | 12.7 | |
>100, ≤400 [44] | 23.1 | 27.9 | 27.9 | |
>400 [28] | 28.6 | 39.4 | 49.7 | |
AFP (nag/mol) | 0.000 | |||
≤150 [402] | 5.8 | 10.1 | 12.4 | |
>150, ≤800 [33] | 39.4 | 45.5 | 45.5 | |
>800 [26] | 34.6 | 34.6 | 45.7 |
HCC, hepatocellular carcinoma; PIVKA-II, protein induced by vitamin K absence or antagonist-II; AFP, α-fetoprotein; UCSF, University of California and San Francisco.