Table 1.
Antifungal activity data of synthesized compounds 3a–d, 4a–d and 5a–l
| Comp | Conc. mg/mL | Zone of inhibition in mm (mean ± S.D.) n = 3 | ||||
|---|---|---|---|---|---|---|
| A.f ± S.D. | C.a ± S.D. | M.g ± S.D. | A.t ± S.D. | C.k ± S.D. | ||
| 3a | 1.6 | 10 ± 0.2 | 10 ± 0.1 | 10 ± 0.2 | 11 ± 0.3 | 08 ± 0.3 |
| 0.64 | 07 ± 0.3 | 08 ± 0.2 | 06 ± 0.1 | 07 ± 0.1 | 06 ± 0.1 | |
| 0.25 | 04 ± 0.1 | 06 ± 0.3 | – | 05 ± 0.1 | – | |
| 3b | 1.6 | 10 ± 0.2 | 11 ± 0.1 | 10 ± 0.2 | 11 ± 0.3 | 08 ± 0.3 |
| 0.64 | 07 ± 0.3 | 10 ± 0.2 | 08 ± 0.1 | 08 ± 0.1 | 07 ± 0.1 | |
| 0.25 | 05 ± 0.1 | 07 ± 0.3 | 05 ± 0.1 | 07 ± 0.1 | 05 ± 0.1 | |
| 3c | 1.6 | 10 ± 0.2 | 12 ± 0.1 | 11 ± 0.2 | 11 ± 0.3 | 09 ± 0.3 |
| 0.64 | 08 ± 0.3 | 10 ± 0.2 | 09 ± 0.1 | 09 ± 0.1 | 07 ± 0.1 | |
| 0.25 | 06 ± 0.1 | – | – | – | – | |
| 3d | 1.6 | 10 ± 0.2 | 13 ± 0.1 | 12 ± 0.2 | 13 ± 0.3 | 09 ± 0.3 |
| 0.64 | 09 ± 0.3 | 11 ± 0.2 | 10 ± 0.1 | 12 ± 0.1 | 07 ± 0.1 | |
| 0.25 | 06 ± 0.1 | 09 ± 0.3 | 08 ± 0.1 | 08 ± 0.1 | 05 ± 0.1 | |
| 4a | 1.6 | 10 ± 0.2 | 15 ± 0.1 | 14 ± 0.2 | 16 ± 0.3 | 09 ± 0.3 |
| 0.64 | 09 ± 0.3 | 12 ± 0.2 | 12 ± 0.1 | 13 ± 0.1 | 08 ± 0.1 | |
| 0.25 | 07 ± 0.1 | 10 ± 0.3 | 09 ± 0.3 | 10 ± 0.1 | 07 ± 0.1 | |
| 4b | 1.6 | 12 ± 0.2 | 17 ± 0.1 | 16 ± 0.2 | 19 ± 0.3 | 10 ± 0.3 |
| 0.64 | 10 ± 0.3 | 15 ± 0.2 | 14 ± 0.1 | 16 ± 0.1 | 08 ± 0.1 | |
| 0.25 | 08 ± 0.1 | 11 ± 0.3 | 11 ± 0.3 | 12 ± 0.1 | 07 ± 0.1 | |
| 4c | 1.6 | 11 ± 0.2 | 17 ± 0.1 | 16 ± 0.2 | 18 ± 0.3 | 10 ± 0.3 |
| 0.64 | 10 ± 0.3 | 14 ± 0.2 | 14 ± 0.1 | 15 ± 0.1 | 08 ± 0.1 | |
| 0.25 | 08 ± 0.1 | 11 ± 0.3 | 10 ± 0.3 | 10 ± 0.1 | 06 ± 0.1 | |
| 4d | 1.6 | 12 ± 0.2 | 18 ± 0.1 | 17 ± 0.2 | 19 ± 0.3 | 11 ± 0.3 |
| 0.64 | 10 ± 0.3 | 16 ± 0.2 | 15 ± 0.1 | 17 ± 0.1 | 09 ± 0.1 | |
| 0.25 | 09 ± 0.1 | 12 ± 0.3 | 12 ± 0.3 | 14 ± 0.1 | 07 ± 0.1 | |
| 5a | 1.6 | 07 ± 0.2 | 07 ± 0.1 | 07 ± 0.2 | 07 ± 0.3 | 06 ± 0.3 |
| 0.64 | 04 ± 0.3 | 04 ± 0.2 | 03 ± 0.1 | 04 ± 0.1 | 04 ± 0.1 | |
| 0.25 | – | – | – | – | – | |
| 5b | 1.6 | 09 ± 0.2 | 08 ± 0.1 | 08 ± 0.2 | 08 ± 0.3 | 07 ± 0.3 |
| 0.64 | 06 ± 0.3 | 06 ± 0.2 | 05 ± 0.1 | 05 ± 0.1 | 06 ± 0.1 | |
| 0.25 | 03 ± 0.1 | 04 ± 0.3 | – | – | – | |
| 5c | 1.6 | 07 ± 0.2 | 07 ± 0.1 | 07 ± 0.2 | 08 ± 0.3 | 07 ± 0.3 |
| 0.64 | 05 ± 0.3 | 05 ± 0.2 | 04 ± 0.1 | 05 ± 0.1 | 05 ± 0.1 | |
| 0.25 | 03 ± 0.1 | 03 ± 0.3 | – | – | 04 ± 0.3 | |
| 5d | 1.6 | 09 ± 0.2 | 09 ± 0.1 | 10 ± 0.2 | 10 ± 0.3 | 08 ± 0.3 |
| 0.64 | 07 ± 0.3 | 07 ± 0.2 | 05 ± 0.1 | 06 ± 0.1 | 06 ± 0.1 | |
| 0.25 | 04 ± 0.1 | 06 ± 0.3 | 04 ± 0.1 | 04 ± 0.1 | 04 ± 0.1 | |
| 5e | 1.6 | 04 ± 0.2 | 04 ± 0.1 | 04 ± 0.2 | 04 ± 0.3 | 04 ± 0.3 |
| 0.64 | 02 ± 0.3 | 02 ± 0.2 | 01 ± 0.1 | – | – | |
| 0.25 | – | – | – | – | – | |
| 5f | 1.6 | 05 ± 0.2 | 04 ± 0.1 | 05 ± 0.2 | 04 ± 0.3 | 05 ± 0.3 |
| 0.64 | 02 ± 0.3 | 03 ± 0.2 | 02 ± 0.1 | 03 ± 0.1 | 04 ± 0.1 | |
| 0.25 | 01 ± 0.3 | 02 ± 0.2 | 01 ± 0.1 | – | 01 ± 0.1 | |
| 5 g | 1.6 | 05 ± 0.2 | 04 ± 0.1 | 04 ± 0.2 | 04 ± 0.3 | 05 ± 0.3 |
| 0.64 | 02 ± 0.3 | 03 ± 0.2 | 02 ± 0.1 | 02 ± 0.1 | 02 ± 0.1 | |
| 0.25 | – | 01 ± 0.2 | – | – | – | |
| 5 h | 1.6 | 05 ± 0.2 | 04 ± 0.1 | 04 ± 0.2 | 04 ± 0.3 | 04 ± 0.3 |
| 0.64 | 02 ± 0.3 | 03 ± 0.2 | 02 ± 0.1 | 01 ± 0.1 | 02 ± 0.1 | |
| 0.25 | – | 01 ± 0.2 | – | – | – | |
| 5i | 1.6 | 05 ± 0.2 | 05 ± 0.1 | 05 ± 0.2 | 05 ± 0.3 | 06 ± 0.3 |
| 0.64 | 03 ± 0.3 | 03 ± 0.2 | 03 ± 0.1 | 03 ± 0.1 | 02 ± 0.1 | |
| 0.25 | – | – | 01 ± 0.1 | – | – | |
| 5j | 1.6 | 06 ± 0.2 | 06 ± 0.1 | 06 ± 0.2 | 06 ± 0.3 | 07 ± 0.3 |
| 0.64 | 05 ± 0.3 | 04 ± 0.2 | 04 ± 0.1 | 03 ± 0.1 | 04 ± 0.1 | |
| 0.25 | 01 ± 0.3 | – | 01 ± 0.3 | 02 ± 0.1 | 02 ± 0.1 | |
| 5 k | 1.6 | 06 ± 0.2 | 06 ± 0.1 | 06 ± 0.2 | 06 ± 0.3 | 06 ± 0.3 |
| 0.64 | 04 ± 0.3 | 03 ± 0.2 | 03 ± 0.1 | 03 ± 0.1 | 04 ± 0.1 | |
| 0.25 | 01 ± 0.1 | – | – | 01 ± 0.1 | 01 ± 0.1 | |
| 5 l | 1.6 | 06 ± 0.2 | 07 ± 0.1 | 07 ± 0.2 | 07 ± 0.3 | 07 ± 0.3 |
| 0.64 | 05 ± 0.3 | 03 ± 0.2 | 05 ± 0.1 | 03 ± 0.1 | 03 ± 0.1 | |
| 0.25 | 03 ± 0.1 | – | 02 ± 0.3 | 02 ± 0.1 | – | |
| Std | 1.6 | 14 ± 0.2 | 20 ± 0.1 | 19 ± 0.2 | 22 ± 0.3 | 12 ± 0.1 |
| 0.64 | 12 ± 0.3 | 18 ± 0.2 | 17 ± 0.1 | 19 ± 0.1 | 10 ± 0.2 | |
| 0.25 | 10 ± 0.1 | 15 ± 0.3 | 14 ± 0.3 | 16 ± 0.1 | 09 ± 0.3 | |
A.f Aspergillus flavus, C.a Candida albicans, M.g Microspora griseus, A.t Aspergillus terreus, C.k Chrysosporium keratinophilum, Stnd fluconazole, S.D. Standard Deviation