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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Neurochem Int. 2016 Dec 3;102:66–78. doi: 10.1016/j.neuint.2016.11.014

Table 1.

Arterial pH, blood gas, and plasma glucose and lactate concentrations.

pH HCO3 pO2 O2 Sat pCO2 Glucose Lactate
Sham n = 10 Pre 7.47 ± 0.01 27.01 ± 0.42 86.22 ± 1.64 97.16 ± 0.21 36.84 ± 0.83 10.18 ± 0.45 0.79 ± 0.13
15 min 7.46 ± 0.01 26.35 ± 0.39 88.20 ± 2.52 97.16 ± 0.27 36.98 ± 0.82 14.40 ± 0.68 1.28 ± 0.10
67 min 7.47 ± 0.01 26.98 ± 0.53 86.30 ± 2.11 97.03 ± 0.25 37.08 ± 1.01 12.81 ± 0.81 1.07 ± 0.14
CCI-SAL n = 9 Pre 7.46 ± 0.01 25.88 ± 0.25 84.33 ± 1.66 96.88 ± 0.20 36.37 ± 0.69 9.58 ± 0.45 0.58 ± 0.03¤
15 min 7.46 ± 0.00 25.89 ± 0.29 86.11 ± 1.49 97.04 ± 0.17 36.62 ± 0.43 13.71 ± 0.41 0.93 ± 0.08
67 min 7.47 ± 0.01 26.43 ± 0.58 86.22 ± 2.99 97.01 ± 0.38 36.38 ± 1.04 12.33 ± 0.52 0.96 ± 0.17
CCI-SP n = 10 Pre 7.58 ± 0.01*ˆ∘¤ 34.78 ± 1.07*ˆ∘¤ 84.00 ± 1.84 97.63 ± 0.18 37.02 ± 0.63 10.71 ± 0.53 0.94 ± 0.06
15 min 7.54 ± 0.01*ˆ∘¤ 33.67 ± 1.01*ˆ¤ 84.80 ± 0.95 97.48 ± 0.07 39.31 ± 0.63 14.32 ± 0.54 1.77 ± 0.15∘
67 min 7.54 ± 0.01*ˆ∘¤ 32.84 ± 0.85*ˆ¤ 84.10 ± 1.48 97.43 ± 0.12 38.19 ± 0.70 11.66 ± 0.52 1.40 ± 0.09
CCI-EP n = 9 Pre 7.48 ± 0.01 27.19 ± 0.32 84.78 ± 1.88 97.06 ± 0.21 36.67 ± 0.68 9.50 ± 0.29 0.66 ± 0.05
15 min 7.48 ± 0.01 27.13 ± 0.33 89.33 ± 1.55 97.46 ± 0.17 36.78 ± 0.97 14.39 ± 0.47 1.19 ± 0.12
67 min 7.48 ± 0.00 28.04 ± 0.45 85.44 ± 0.91 97.19 ± 0.09 37.51 ± 0.77 12.22 ± 0.71 0.92 ± 0.07
CCI-GLC n = 10 Pre 7.48 ± 0.01 27.61 ± 0.41 83.80 ± 1.76 96.98 ± 0.23 36.89 ± 0.70 11.74 ± 1.22 1.26 ± 0.28
15 min 7.48 ± 0.01 26.96 ± 0.53 87.10 ± 1.58 97.36 ± 0.14 36.41 ± 0.97 16.14 ± 1.09 1.76 ± 0.15ˆ∘
67 min 7.48 ± 0.01 27.73 ± 0.53 86.10 ± 1.32 97.27 ± 0.16 36.76 ± 0.77 13.25 ± 0.90 1.24 ± 0.18

CCI, controlled cortical impact; EP, ethyl pyruvate; GLC, glucose; HCO3, bicarbonate; O2 Sat, oxygen saturation; pCO2, partial pressure of carbon dioxide in mm Hg; pO2, partial pressure of oxygen in mm Hg; SAL, saline; SP, sodium pyruvate.

The concentration of plasma glucose and lactate are expressed as mmol/L.

All values are expressed as mean ± SEM. Effects of Group (*p < 0.05 vs. Sham; ˆ p < 0.05 vs. CCI–SAL; ŧ p < 0.05 vs. CCI–SP; ∘ p < 0.05 vs. CCI–EP, ¤ p < 0.05 vs. CCI–GLC) on pH, HCO3, or lactate were evaluated using repeated measures one-way ANCOVA with Bonferroni post-hoc analysis and controlling for the effect of pre-infusion (Pre) pH, HCO3, or lactate levels.

Group effects on pO2, pCO2, O2 saturation, and glucose were evaluated using repeated measures one-way ANOVA with Bonferroni post-hoc analysis.