Table 1.
Cytotoxic activity (IC50) of betulin 1, derivatives of betulin and cisplatin as a reference compound against the four cancer cell lines
| Compound | Cytotoxic activity IC50 [μg/mL] | ||||
|---|---|---|---|---|---|
| Human | Murine | ||||
| T47D | CCRF/CEM | SW707 | P388 | BALB3T3 | |
| Betulin 1 | 32.4 ± 10.7 | 10.9 ± 5.5 | 22.9 ± 15.4 | 5.5 ± 3.3 | 47.3 ± 7.9 |
| 3 a | 12.1 ± 4.4 | 8.1 ± 0.9 | 29.2 ± 24.4 | 3.3 ± 0.8 | 32.3 ± 23.0 |
| 4 | 7.1 ± 2.7 | 19.6 ± 9.5 | 29.6 ± 4.2 | 9.9 ± 5.9 | 24.3 ± 6.9 |
| 5 a | 9.1 ± 1.9 | 0.02 ± 0.001 | 14.9 ± 3.3 | 0.4 ± 0.1 | 0.3 ± 0.05 |
| 6 | 33.6 ± 6.3 | 16.5 ± 8.5 | Neg | 8.4 ± 9.2 | Neg |
| 7 a | Neg | 49.0 ± 9.8 | Neg | Neg | Neg |
| 8 | 29.9 ± 9.3 | 28.0 ± 21.6 | 32.0 ± 4.2 | 5.1 ± 4.9 | 25.6 ± 1.8 |
| 9 | 16.7 ± 5.5 | 2.1 ± 0.3 | 24.3 ± 8.8 | 2.9 ± 1.4 | 17.4 ± 1.1 |
| 19 | Neg | Neg | Neg | Neg | Neg |
| 24 | 23.3 ± 3.5 | 18.7 ± 6.6 | Neg | 30.3 ± 11.8 | Neg |
| 25 | 29.8 ± 10.7 | 25.2 ± 4.6 | Neg | 3.8 ± 1.9 | Neg |
| 26 | 79.2 ± 5.2 | 47.6 ± 5.7 | Neg | 18.3 ± 12.9 | Neg |
| Cisplatin | 3.1 ± 1.0 | 2.0 ± 0.5 | 2.2 ± 0.5 | 0.5 ± 0.3 | 2.7 ± 0.3 |