Fig. 3.

Multiple pathways ensure centrosome assembly, which is compromised in cancer cells. In non-transformed cells (left), centriolar assembly is apparently normal upon depletion of MSD1/SSX2IP, although the microtubule network is disorganised. Alternate compensatory pathways that ensure building of the proper centriole structure may be exploited in these cells. On the other hand, the absence of MSD1/SSX2IP leads to alteration of centriolar satellite organisation in many cancer cells (right); centriolar satellites carry centriolar/centrosomal components and are stuck at microtubule minus ends in the vicinity of the centrosome, leading to faulty assembly of centrioles