TABLE 2.

Susceptibility of Leptospira strains to 24 antimicrobial agents or combinations of agents

Strain no.	Median MIC (μg/ml)a
	Doxycycline	Tetracycline	Chloramphenicol	Penicillin G	Amoxicillin	Ampicillin	Ampicillin-sulbactamb	Cefoxitin	Cefdinir	Ceftriaxone	Cefotaxime	Cefepime	Imipenem-cilastatinc	Ertapenem	Aztreonam	Erythromycin	Azithromycin	Clarithromycin	Telithromycin	Ciprofloxacin	Moxifloxacin	Levofloxacin	Gatifloxacin	Garenoxacin
1	0.05	0.05	0.78	6.25	3.13	0.78	0.1	≤0.01	0.78	≤0.01	≤0.01	≤0.01	≤0.01	≤0.01	12.5	≤0.01	≤0.01	≤0.01	≤0.01	≤0.01	≤0.01	≤0.01	≤0.01	<0.01
2	0.78	0.78	3.13	6.25	3.13	0.78	0.2	≤0.01	3.13	0.1	0.1	≤0.01	≤0.01	0.02	>25	≤0.01	≤0.01	≤0.01	≤0.01	≤0.01	≤0.01	≤0.01	≤0.01	≤0.01
3	0.39	0.78	6.25	0.78	0.39	0.39	0.1	≤0.01	1.56	0.1	≤0.01	≤0.01	≤0.01	≤0.01	>25	≤0.01	≤0.01	≤0.01	≤0.01	0.05	0.2	0.1	0.05	≤0.01
4	0.2	0.2	0.78	1.56	0.2	0.1	0.1	≤0.01	1.56	0.02	≤0.01	≤0.01	≤0.01	≤0.01	>25	≤0.01	≤0.01	≤0.01	≤0.01	0.05	0.1	0.05	0.02	≤0.01
5	0.1	0.1	0.78	3.13	0.39	0.39	0.1	≤0.01	3.13	0.02	0.02	≤0.01	≤0.01	≤0.01	>25	≤0.01	≤0.01	≤0.01	≤0.01	≤0.01	0.05	0.02	≤0.01	≤0.01
6	0.2	0.39	3.13	0.39	0.02	0.05	0.02	0.05	0.78	≤0.01	≤0.01	≤0.01	≤0.01	≤0.01	>25	≤0.01	0.02	≤0.01	≤0.01	0.2	0.2	0.1	0.05	0.02
7	0.39	0.39	1.56	6.25	0.78	1.56	0.2	0.2	3.13	0.1	0.05	≤0.01	≤0.01	0.02	>25	≤0.01	≤0.01	≤0.01	≤0.01	0.02	0.1	0.05	≤0.01	≤0.01
8	0.39	0.39	3.13	3.13	0.05	0.2	0.05	0.1	3.13	0.2	0.05	≤0.01	≤0.01	≤0.01	>25	≤0.01	0.05	≤0.01	≤0.01	0.1	0.2	0.1	0.02	0.02
9	0.1	0.1	0.78	0.1	≤0.01	0.02	≤0.01	0.05	0.78	≤0.01	≤0.01	≤0.01	≤0.01	≤0.01	>25	≤0.01	≤0.01	≤0.01	≤0.01	0.02	0.05	0.05	≤0.01	≤0.01
10	0.39	0.78	6.25	0.39	0.05	0.1	0.02	0.1	0.78	0.02	0.02	≤0.01	≤0.01	≤0.01	>25	≤0.01	0.02	≤0.01	≤0.01	0.1	0.1	0.1	0.05	0.02
11	0.39	0.39	6.25	0.39	≤0.01	0.02	0.02	0.05	1.56	0.02	0.02	≤0.01	≤0.01	≤0.01	>25	≤0.01	≤0.01	≤0.01	≤0.01	0.1	0.1	0.05	0.02	≤0.01
12	0.2	0.2	3.13	3.13	0.1	0.2	0.05	0.05	3.13	0.1	0.02	≤0.01	≤0.01	≤0.01	>25	≤0.01	≤0.01	≤0.01	≤0.01	0.05	0.05	0.05	≤0.01	≤0.01
13	0.39	0.78	3.13	0.39	≤0.01	≤0.01	0.02	0.1	0.78	0.05	0.02	≤0.01	≤0.01	≤0.01	>25	≤0.01	0.02	≤0.01	≤0.01	0.2	0.1	0.1	0.05	≤0.01
14	0.2	0.2	1.56	3.13	1.56	0.78	0.1	0.05	3.13	0.05	≤0.01	≤0.01	≤0.01	≤0.01	>25	≤0.01	≤0.01	≤0.01	≤0.01	0.05	0.1	0.05	0.02	≤0.01
15	0.78	0.78	6.25	3.13	0.02	0.1	0.05	0.2	3.13	0.39	0.1	≤0.01	≤0.01	0.02	>25	≤0.01	≤0.01	≤0.01	≤0.01	0.1	0.05	0.1	0.05	0.02
16	6.25	3.13	6.25	0.39	≤0.01	0.02	≤0.01	0.05	3.13	0.1	0.02	≤0.01	≤0.01	≤0.01	>25	≤0.01	≤0.01	≤0.01	≤0.01	0.2	0.1	0.1	0.05	0.02
17	0.2	0.1	1.56	0.02	≤0.01	≤0.01	≤0.01	0.02	0.78	≤0.01	≤0.01	≤0.01	≤0.01	≤0.01	>25	≤0.01	≤0.01	≤0.01	≤0.01	0.1	0.1	0.1	0.05	0.02
18	0.2	0.39	3.13	1.56	0.05	0.2	0.05	0.1	3.13	0.05	0.02	≤0.01	≤0.01	≤0.01	>25	≤0.01	≤0.01	≤0.01	≤0.01	0.1	0.1	0.1	0.05	≤0.01
19	0.2	0.2	1.56	25	3.13	1.56	0.39	0.1	3.13	0.2	0.1	≤0.01	≤0.01	0.02	>25	≤0.01	≤0.01	≤0.01	≤0.01	0.05	0.1	0.05	≤0.01	≤0.01
20	1.56	6.25	6.25	12.5	3.13	3.13	0.39	0.1	0.78	0.78	0.1	0.02	0.02	0.02	>25	≤0.01	0.05	≤0.01	≤0.01	0.05	0.05	0.05	0.02	0.05
21	0.39	0.2	3.13	0.1	0.1	0.05	0.02	≤0.01	0.39	≤0.01	≤0.01	≤0.01	≤0.01	≤0.01	>25	≤0.01	≤0.01	≤0.01	≤0.01	0.02	0.1	0.05	0.02	≤0.01
22	0.78	0.78	6.25	3.13	0.1	0.2	0.05	0.1	6.25	0.39	0.1	0.02	≤0.01	0.05	>25	≤0.01	≤0.01	≤0.01	≤0.01	0.2	0.2	0.1	0.02	0.02
23	3.13	1.56	6.25	0.1	0.02	0.05	0.05	0.02	6.25	0.1	0.02	≤0.01	≤0.01	≤0.01	>25	≤0.01	≤0.01	≤0.01	≤0.01	0.1	0.1	0.1	0.05	0.02
24	0.2	0.2	3.13	0.1	0.05	0.05	0.02	0.05	3.13	0.2	≤0.01	≤0.01	≤0.01	≤0.01	>25	≤0.01	≤0.01	≤0.01	≤0.01	0.2	0.1	0.1	0.02	≤0.01
25	0.78	0.78	6.25	3.13	0.78	0.39	0.1	0.05	1.56	0.2	0.05	≤0.01	≤0.01	≤0.01	>25	≤0.01	≤0.01	≤0.01	≤0.01	0.05	0.1	0.1	0.05	0.02
26	0.2	0.39	1.56	1.56	0.78	0.78	0.2	0.1	1.56	0.1	0.05	≤0.01	≤0.01	0.02	>25	≤0.01	≤0.01	≤0.01	≤0.01	0.1	0.1	0.1	0.05	≤0.01
MIC90d	1.56	1.56	6.25	6.25	3.13	1.56	0.2	0.1	3.13	0.39	0.1	≤0.01	≤0.01	0.02	>25	≤0.01	0.02	≤0.01	≤0.01	0.2	0.2	0.1	0.05	0.02

^aMICs of penicillin G are given in units per milliliter.

^bMICs of ampicillin-subactam are based on ampicillin concentrations.

^cMICs of imipenem-cilastatin are based on imipenem concentrations.

^dCumulative susceptibility results across all serovars are expressed as MIC₉₀, the concentration at which 90% of the Leptospira isolates are inhibited.