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. 2016 Oct 11;38(1):40–50. doi: 10.1093/carcin/bgw106

Figure 2.

Figure 2.

The effect of silibinin treatment on different stages of UVB-induced skin tumorigenesis in SKH-1 p53+/+ and p53+/− mice. p53+/+ and p53+/− mice were exposed to UVB alone (90 mJ/cm2) with or without topical application of silibinin (9 mg in 200 µl acetone) either prior to UVB (Sb + UV), or immediately after UVB exposure (UV + Sb) 5 days per week for 25 weeks all as detailed in Materials and Methods. (A) Representative H&E images of different stages of skin tumor development (per 200× field). (B) The percent incidences of different stages of tumor development in each respective group (n = 6–8 mice in each group).