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FFAR2 deficiency dysregulated the cAMP-PKA-CREB-HDAC pathway, and BRBs restored that pathway in the ApcMin/+ mice but not the ApcMin/+-FFAR2−/− mice. Representative immunohistochemical staining and quantitative results for cAMP, phosphor-PKA (p-PKA), phosphor-CREB (p-CREB), HDAC2, HDAC4 and acetyl H3 from the ApcMin/+ mice and ApcMin/+-FFAR2−/− mice fed a control diet or a BRB diet. Only staining in adenoma areas was quantified. n = 4–6. *P < 0.05.
