TABLE 2.
Inhibitory effects of plant lectins against wild-type (NL4.3) and binding/fusion-inhibitor-resistant HIV-1 strains in MT-4 cell cultures
| Virus strain | Mean EC50a (μg/ml) ± SD
|
|||
|---|---|---|---|---|
| GNA | HHA | AMD3100 | DS-5000b | |
| Wild-type NL4.3 | 0.57 ± 0.15 | 0.22 ± 0.14 | 0.005 ± 0.001 | 0.14 |
| AMD3100-resistant NL4.3 | 0.59 ± 0.19 | 0.24 ± 0.14 | >1.0 | |
| SDF-1-resistant NL4.3 | 0.60 ± 0.0 | 0.55 ± 0.22 | 0.023 ± 0.003 | |
| Dextran sulfate-5000-resistant NL4.3 | 0.13 ± 0.08 | 0.23 ± 0.12 | 0.011 ± 0.006 | >125 |
a
That is, the compound concentration required to inhibit virus-induced cytopathicity by 50% in MT-4 cell cultures. Data are means for two independent experiments.
b
Data were obtained from Esté et al. (18).