TABLE 3.
Inhibitory effects of lectins on giant cell formation upon cocultivation of HUT-78/HIV-1 or HUT-78/HIV-2 cells with Sup-T1 or Molt4/C8 cells
| Lectin | Mean EC50a (μg/ml) ± SD
|
||
|---|---|---|---|
| HUT-78/HIV-1 + Sup-T1 | HUT-78/HIV-2 + Sup-T1 | HUT-78/HIV-2 + Molt4/C8 | |
| GNA | 1.25 ± 0.35 | 80 ± 28 | 15 ± 7.0 |
| HHA | 1.25 ± 0.35 | 9.0 ± 1.4 | 2.3 ± 0.28 |
| UC-781 | >10 | >10 | >10 |
| AMD3100 | 3.7 ± 1.7 | ≥100 | 11 ± 3.5 |
| DS-5000 | 2.7 ± 1.5 | 10 ± 2.8 | >100 |
a
That is, the compound concentration required to prevent syncytium formation between persistently HIV-infected cells and uninfected cells by 50% within the first 24 h of cocultivation. The number of syncytia was determined under a microscope. Data are the means of two independent experiments.