TABLE 1.
Fluconazole and itraconazole MICs for C. glabrata azole-susceptible and resistant isolates and laboratory mutantsa
| Strain | MIC (μg/ml)b
|
|
|---|---|---|
| FLU | ITR | |
| Susceptible | ||
| 66032 | 16 | 0.5 |
| 2001 | 16 | 0.5 |
| 38326 | 16 | 0.5 |
| 945 | 16 | 0.5 |
| 380 | 32 | 1 |
| Resistant clinical | ||
| 381 | >128 | >8 |
| 34-031-010 | 128 | >8 |
| 34-031-014 | >128 | >8 |
| 34-016-031 | >128 | >8 |
| 34-507-038-02 | >128 | >8 |
| 34-016-042 | 128 | >8 |
| 34-028-092 | >128 | >8 |
| 34-028-056 | 128 | >8 |
| 33-94-R-0024-119 | 128 | >8 |
| 34-517-502 | >128 | >8 |
| 34-028-512 | >128 | >8 |
| 34-019-018 | >128 | >8 |
| Laboratory resistant | ||
| F15 | >128 | >8 |
| F17 | >128 | 4 |
| F18 | 128 | 8 |
| F22 | 64 | 0.5 |
| F23 | >128 | 8 |
| F25 | >128 | >8 |
a
Susceptible strains were from the American Type Culture Collection, except 380 and 945 (46). Clinical resistant strains were from MSG33-34 (33) except 381 (46); underlining indicates a strain abbreviation used in Fig. 1A and Fig. 5. Laboratory resistant mutants were derived from ATCC 66032 (F, fluconazole resistant). MICs were determined in YPD and read at 24 h.
b
FLU, fluconazole; ITR, itraconazole.