TABLE 3.
MICs for 12 strains tested by time-kill method
| Drug | MIC (μg/ml) for strain:
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1a | 2a | 3a | 4a | 5b | 6b | 7b | 8b | 9c | 10c | 11d | 12d | |
| LBM415 | 0.12 | 2.0 | 2.0 | 2.0 | 0.12 | 0.25 | 0.5 | 0.25 | 0.5 | 0.5 | 0.5 | 1.0 |
| Amoxicillin | 0.016 | 2.0 | 2.0 | 2.0 | 0.25 | 0.03 | 0.06 | 0.06 | 2.0 | 2.0 | 2.0 | 0.03 |
| Amoxicillin-clavulanate | 0.016 | 2.0 | 2.0 | 2.0 | 0.12 | 0.03 | 0.03 | 0.12 | 2.0 | 2.0 | 2.0 | 0.016 |
| Imipenem | 0.004 | 0.25 | 0.25 | 0.25 | 0.03 | 0.008 | 0.008 | 0.03 | 0.25 | 0.12 | 0.25 | 0.008 |
| Meropenem | 0.008 | 0.5 | 0.5 | 1.0 | 0.06 | 0.016 | 0.016 | 0.06 | 0.5 | 0.25 | 0.5 | 0.016 |
| Ceftriaxone | 0.016 | 2.0 | 2.0 | 2.0 | 0.12 | 0.016 | 0.06 | 0.06 | 2.0 | 2.0 | 4.0 | 0.03 |
| Cefuroxime | 0.016 | 2.0 | 2.0 | 4.0 | 0.25 | 0.03 | 0.12 | 0.25 | 8.0 | 16.0 | 16.0 | 0.03 |
| Cefdinir | 0.06 | 4.0 | 4.0 | 4.0 | 0.12 | 0.12 | 0.03 | 0.06 | 8.0 | 8.0 | 16.0 | 0.12 |
| Ciprofloxacin | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 4.0 | 4.0 | 2.0 | 2.0 | 1.0 | 8.0 | >32.0 |
| Levofloxacin | 1.0 | 1.0 | 1.0 | 1.0 | 1.0 | 2.0 | 1.0 | 1.0 | 2.0 | 1.0 | 8.0 | 16.0 |
| Gatifloxacin | 1.0 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.25 | 0.5 | 0.5 | 4.0 | 8.0 |
| Moxifloxacin | 0.12 | 0.25 | 0.25 | 0.25 | 0.25 | 0.25 | 0.25 | 0.12 | 0.25 | 0.25 | 2.0 | 4.0 |
| Azithromycin | >64 | >64 | >64 | >64 | 8.0 | 8.0 | 16.0 | 2.0 | >64 | >64 | 0.06 | 0.125 |
| Clarithromycin | 64 | >64 | >64 | >64 | 2.0 | 4.0 | 8.0 | 2.0 | 16 | 32 | 0.016 | 0.03 |
| Linezolid | 0.5 | 2.0 | 1.0 | 1.0 | 0.5 | 1.0 | 1.0 | 0.5 | 2.0 | 2.0 | 1.0 | 1.0 |
| Quinupristin-dalfopristin | 0.5 | 1.0 | 0.5 | 0.5 | 0.25 | 0.25 | 0.5 | 0.25 | 0.5 | 0.5 | 0.25 | 0.25 |
| Daptomycin | 0.12 | 0.25 | 0.25 | 0.5 | 0.12 | 0.25 | 0.25 | 0.25 | 0.25 | 0.25 | 0.12 | 0.25 |
| Vancomycin | 0.25 | 0.5 | 0.5 | 0.25 | 0.25 | 0.25 | 0.25 | 0.25 | 0.25 | 0.25 | 0.25 | 0.5 |
| Teicoplanin | 0.06 | 0.12 | 0.06 | 0.12 | 0.06 | 0.12 | 0.12 | 0.06 | 0.06 | 0.12 | 0.12 | 0.06 |
a
Macrolide-resistant strains carrying the erm(B) mutation.
b
Macrolide-resistant strains carrying the mef(A) mutation.
c
Macrolide-resistant strains carrying an L4 protein mutation.
d
Quinolone-resistant strains (ciprofloxacin MIC, ≥8.0 μg/ml).