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. 2004 Oct;48(10):4027–4032. doi: 10.1128/AAC.48.10.4027-4032.2004

TABLE 4.

Pneumococcal killing kinetics results

Drug and multiple of MIC No. of isolates for which the level of killinga was as indicated at the following times:
3 h
6 h
12 h
24 h
−1 −2 −3 −1 −2 −3 −1 −2 −3 −1 −2 −3
LBM415
    4 0 0 0 4 1 0 9 2 2 12 9 8
    2 0 0 0 3 1 0 9 2 2 10 8 6
    1 0 0 0 2 0 0 8 1 1 7 4 2
Amoxicillin
    4 12 7 0 12 11 6 12 12 11 12 12 12
    2 9 4 0 12 10 6 12 11 10 12 12 12
    1 7 3 0 10 9 3 12 10 8 12 11 9
Amoxicillin-clavulanate
    4 11 6 1 12 11 7 12 11 10 12 12 12
    2 10 6 1 12 11 7 12 11 10 12 12 12
    1 9 3 1 12 10 3 12 11 9 11 11 10
Imipenem
    4 12 7 0 12 10 5 12 12 11 12 12 12
    2 12 5 0 12 10 5 12 12 11 12 12 12
    1 11 4 0 11 6 4 12 11 8 12 11 10
Meropenem
    4 11 4 2 12 9 3 12 12 10 12 12 12
    2 9 3 1 12 7 3 12 11 9 12 12 12
    1 8 2 1 11 7 3 11 7 4 8 7 5
Ceftriaxone
    4 7 2 0 12 6 2 12 12 10 12 12 12
    2 6 2 0 12 7 3 12 12 10 12 11 10
    1 4 1 0 8 5 3 9 9 6 11 8 4
Cefuroxime
    4 11 3 2 12 10 3 12 11 10 12 12 12
    2 11 3 0 12 9 3 12 11 10 12 12 11
    1 9 1 0 12 9 2 12 11 9 11 10 9
Cepodoxime
    4 11 3 0 12 12 4 12 12 10 12 12 12
    2 11 3 0 12 12 3 12 12 10 12 12 12
    1 9 2 0 12 10 3 12 10 9 12 11 11
Cefdinir
    4 10 5 1 12 9 5 12 12 11 12 12 12
    2 9 3 0 12 9 5 12 11 10 12 12 12
    1 4 3 0 10 6 2 12 7 4 9 7 5
Ciprofloxacinb
    4 9 6 0 10 10 4 10 10 10 10 10 10
    2 9 3 0 10 10 3 10 10 7 10 9 9
    1 6 1 0 9 6 1 10 9 4 8 7 5
Levofloxacinb
    4 7 2 0 10 10 3 10 10 10 10 10 10
    2 5 0 0 10 6 1 10 10 6 10 10 10
    1 5 0 0 8 4 1 10 8 3 9 9 5
Gatifloxacinb
    4 10 3 0 10 8 1 10 10 8 10 10 9
    2 6 1 0 10 7 1 10 10 7 10 10 9
    1 4 0 0 7 2 1 10 6 3 9 8 4
Moxifloxacinb
    4 10 3 0 10 10 3 10 10 9 10 10 10
    2 8 1 0 10 6 2 10 10 9 10 10 10
    1 5 0 0 8 4 1 9 8 5 10 8 7
Azithromycinc
    4 2 0 0 2 1 1 2 2 2 2 2 2
    2 1 0 0 1 1 1 2 2 2 2 2 2
    1 1 0 0 1 1 1 2 1 1 2 2 2
Clarithromycinc
    4 0 0 0 2 2 0 2 2 2 2 2 2
    2 0 0 0 2 2 0 2 2 2 2 2 2
    1 0 0 0 2 1 0 2 2 2 2 2 2
Linezolid
    4 1 0 0 9 1 1 12 7 3 12 12 9
    2 0 0 0 4 1 1 11 4 1 12 11 7
    1 0 0 0 2 0 0 6 1 0 8 4 2
Quinupristin-dalfopristin
    4 11 10 6 12 11 9 12 11 11 12 12 12
    2 11 9 5 12 11 9 12 11 11 12 12 12
    1 10 7 4 12 11 6 11 10 7 7 5 3
Daptomycin
    4 11 8 2 12 11 9 12 11 11 12 12 12
    2 10 4 2 12 11 8 12 11 11 12 11 11
    1 7 2 2 12 11 4 11 10 7 8 5 3
Vancomycin
    4 4 2 0 12 6 3 12 11 10 12 12 12
    2 4 1 0 12 6 3 12 11 9 12 12 12
    1 4 0 0 12 5 2 12 11 9 11 10 9
Teicoplanin
    4 0 0 0 6 1 0 11 7 4 12 12 11
    2 0 0 0 6 1 0 10 7 4 12 12 10
    1 0 0 0 5 1 0 9 6 3 9 8 7
a

−1, −1 log10 CFU/ml (90% killing); −2, −2 log10 CFU/ml (99% killing); −3, −3 log10 CFU/ml (99.9% killing).

b

Ten strains for which the ciprofloxacin MIC was <8.0 μg/ml were tested.

c

Two macrolide-sensitive strains (erythromycin MIC, 0.03 μg/ml) were tested.