TABLE 4.
Drug and multiple of MIC | No. of isolates for which the level of killinga was as indicated at the following times:
|
|||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
3 h
|
6 h
|
12 h
|
24 h
|
|||||||||
−1 | −2 | −3 | −1 | −2 | −3 | −1 | −2 | −3 | −1 | −2 | −3 | |
LBM415 | ||||||||||||
4 | 0 | 0 | 0 | 4 | 1 | 0 | 9 | 2 | 2 | 12 | 9 | 8 |
2 | 0 | 0 | 0 | 3 | 1 | 0 | 9 | 2 | 2 | 10 | 8 | 6 |
1 | 0 | 0 | 0 | 2 | 0 | 0 | 8 | 1 | 1 | 7 | 4 | 2 |
Amoxicillin | ||||||||||||
4 | 12 | 7 | 0 | 12 | 11 | 6 | 12 | 12 | 11 | 12 | 12 | 12 |
2 | 9 | 4 | 0 | 12 | 10 | 6 | 12 | 11 | 10 | 12 | 12 | 12 |
1 | 7 | 3 | 0 | 10 | 9 | 3 | 12 | 10 | 8 | 12 | 11 | 9 |
Amoxicillin-clavulanate | ||||||||||||
4 | 11 | 6 | 1 | 12 | 11 | 7 | 12 | 11 | 10 | 12 | 12 | 12 |
2 | 10 | 6 | 1 | 12 | 11 | 7 | 12 | 11 | 10 | 12 | 12 | 12 |
1 | 9 | 3 | 1 | 12 | 10 | 3 | 12 | 11 | 9 | 11 | 11 | 10 |
Imipenem | ||||||||||||
4 | 12 | 7 | 0 | 12 | 10 | 5 | 12 | 12 | 11 | 12 | 12 | 12 |
2 | 12 | 5 | 0 | 12 | 10 | 5 | 12 | 12 | 11 | 12 | 12 | 12 |
1 | 11 | 4 | 0 | 11 | 6 | 4 | 12 | 11 | 8 | 12 | 11 | 10 |
Meropenem | ||||||||||||
4 | 11 | 4 | 2 | 12 | 9 | 3 | 12 | 12 | 10 | 12 | 12 | 12 |
2 | 9 | 3 | 1 | 12 | 7 | 3 | 12 | 11 | 9 | 12 | 12 | 12 |
1 | 8 | 2 | 1 | 11 | 7 | 3 | 11 | 7 | 4 | 8 | 7 | 5 |
Ceftriaxone | ||||||||||||
4 | 7 | 2 | 0 | 12 | 6 | 2 | 12 | 12 | 10 | 12 | 12 | 12 |
2 | 6 | 2 | 0 | 12 | 7 | 3 | 12 | 12 | 10 | 12 | 11 | 10 |
1 | 4 | 1 | 0 | 8 | 5 | 3 | 9 | 9 | 6 | 11 | 8 | 4 |
Cefuroxime | ||||||||||||
4 | 11 | 3 | 2 | 12 | 10 | 3 | 12 | 11 | 10 | 12 | 12 | 12 |
2 | 11 | 3 | 0 | 12 | 9 | 3 | 12 | 11 | 10 | 12 | 12 | 11 |
1 | 9 | 1 | 0 | 12 | 9 | 2 | 12 | 11 | 9 | 11 | 10 | 9 |
Cepodoxime | ||||||||||||
4 | 11 | 3 | 0 | 12 | 12 | 4 | 12 | 12 | 10 | 12 | 12 | 12 |
2 | 11 | 3 | 0 | 12 | 12 | 3 | 12 | 12 | 10 | 12 | 12 | 12 |
1 | 9 | 2 | 0 | 12 | 10 | 3 | 12 | 10 | 9 | 12 | 11 | 11 |
Cefdinir | ||||||||||||
4 | 10 | 5 | 1 | 12 | 9 | 5 | 12 | 12 | 11 | 12 | 12 | 12 |
2 | 9 | 3 | 0 | 12 | 9 | 5 | 12 | 11 | 10 | 12 | 12 | 12 |
1 | 4 | 3 | 0 | 10 | 6 | 2 | 12 | 7 | 4 | 9 | 7 | 5 |
Ciprofloxacinb | ||||||||||||
4 | 9 | 6 | 0 | 10 | 10 | 4 | 10 | 10 | 10 | 10 | 10 | 10 |
2 | 9 | 3 | 0 | 10 | 10 | 3 | 10 | 10 | 7 | 10 | 9 | 9 |
1 | 6 | 1 | 0 | 9 | 6 | 1 | 10 | 9 | 4 | 8 | 7 | 5 |
Levofloxacinb | ||||||||||||
4 | 7 | 2 | 0 | 10 | 10 | 3 | 10 | 10 | 10 | 10 | 10 | 10 |
2 | 5 | 0 | 0 | 10 | 6 | 1 | 10 | 10 | 6 | 10 | 10 | 10 |
1 | 5 | 0 | 0 | 8 | 4 | 1 | 10 | 8 | 3 | 9 | 9 | 5 |
Gatifloxacinb | ||||||||||||
4 | 10 | 3 | 0 | 10 | 8 | 1 | 10 | 10 | 8 | 10 | 10 | 9 |
2 | 6 | 1 | 0 | 10 | 7 | 1 | 10 | 10 | 7 | 10 | 10 | 9 |
1 | 4 | 0 | 0 | 7 | 2 | 1 | 10 | 6 | 3 | 9 | 8 | 4 |
Moxifloxacinb | ||||||||||||
4 | 10 | 3 | 0 | 10 | 10 | 3 | 10 | 10 | 9 | 10 | 10 | 10 |
2 | 8 | 1 | 0 | 10 | 6 | 2 | 10 | 10 | 9 | 10 | 10 | 10 |
1 | 5 | 0 | 0 | 8 | 4 | 1 | 9 | 8 | 5 | 10 | 8 | 7 |
Azithromycinc | ||||||||||||
4 | 2 | 0 | 0 | 2 | 1 | 1 | 2 | 2 | 2 | 2 | 2 | 2 |
2 | 1 | 0 | 0 | 1 | 1 | 1 | 2 | 2 | 2 | 2 | 2 | 2 |
1 | 1 | 0 | 0 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 2 | 2 |
Clarithromycinc | ||||||||||||
4 | 0 | 0 | 0 | 2 | 2 | 0 | 2 | 2 | 2 | 2 | 2 | 2 |
2 | 0 | 0 | 0 | 2 | 2 | 0 | 2 | 2 | 2 | 2 | 2 | 2 |
1 | 0 | 0 | 0 | 2 | 1 | 0 | 2 | 2 | 2 | 2 | 2 | 2 |
Linezolid | ||||||||||||
4 | 1 | 0 | 0 | 9 | 1 | 1 | 12 | 7 | 3 | 12 | 12 | 9 |
2 | 0 | 0 | 0 | 4 | 1 | 1 | 11 | 4 | 1 | 12 | 11 | 7 |
1 | 0 | 0 | 0 | 2 | 0 | 0 | 6 | 1 | 0 | 8 | 4 | 2 |
Quinupristin-dalfopristin | ||||||||||||
4 | 11 | 10 | 6 | 12 | 11 | 9 | 12 | 11 | 11 | 12 | 12 | 12 |
2 | 11 | 9 | 5 | 12 | 11 | 9 | 12 | 11 | 11 | 12 | 12 | 12 |
1 | 10 | 7 | 4 | 12 | 11 | 6 | 11 | 10 | 7 | 7 | 5 | 3 |
Daptomycin | ||||||||||||
4 | 11 | 8 | 2 | 12 | 11 | 9 | 12 | 11 | 11 | 12 | 12 | 12 |
2 | 10 | 4 | 2 | 12 | 11 | 8 | 12 | 11 | 11 | 12 | 11 | 11 |
1 | 7 | 2 | 2 | 12 | 11 | 4 | 11 | 10 | 7 | 8 | 5 | 3 |
Vancomycin | ||||||||||||
4 | 4 | 2 | 0 | 12 | 6 | 3 | 12 | 11 | 10 | 12 | 12 | 12 |
2 | 4 | 1 | 0 | 12 | 6 | 3 | 12 | 11 | 9 | 12 | 12 | 12 |
1 | 4 | 0 | 0 | 12 | 5 | 2 | 12 | 11 | 9 | 11 | 10 | 9 |
Teicoplanin | ||||||||||||
4 | 0 | 0 | 0 | 6 | 1 | 0 | 11 | 7 | 4 | 12 | 12 | 11 |
2 | 0 | 0 | 0 | 6 | 1 | 0 | 10 | 7 | 4 | 12 | 12 | 10 |
1 | 0 | 0 | 0 | 5 | 1 | 0 | 9 | 6 | 3 | 9 | 8 | 7 |
−1, −1 log10 CFU/ml (90% killing); −2, −2 log10 CFU/ml (99% killing); −3, −3 log10 CFU/ml (99.9% killing).
Ten strains for which the ciprofloxacin MIC was <8.0 μg/ml were tested.
Two macrolide-sensitive strains (erythromycin MIC, 0.03 μg/ml) were tested.