TABLE 3.
MICs for strains tested by time-kill assays
| Drug | MIC (μg/ml)a
|
|||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SA8 | SA9 | SA12 | SA13 | SA16 | SA19 | CN3 | CN6 | CN20 | CN5 | CN11 | CN18 | |
| LBM415 | 1 | 0.25 | 0.25 | 1 | 1 | 0.5 | 2 | 2 | 0.5 | 2 | 2 | 1 |
| Ciprofloxacin | 0.5 | 1 | 0.5 | >32 | >32 | 32 | 0.25 | 0.25 | 0.25 | 0.25 | >32 | 16 |
| Levofloxacin | 0.25 | 0.25 | 0.25 | 32 | 32 | 16 | 0.25 | 0.25 | 0.25 | 0.25 | 32 | 8 |
| Gatifloxacin | 0.125 | 0.125 | 0.125 | 4 | 16 | 4 | 0.125 | 0.125 | 0.125 | 0.125 | 4 | 2 |
| Moxifloxacin | 0.06 | 0.03 | 0.06 | 4 | 8 | 2 | 0.125 | 0.06 | 0.06 | 0.06 | 8 | 2 |
| Vancomycin | 1 | 1 | 1 | 1 | 2 | 1 | 2 | 2 | 2 | 4 | 2 | 4 |
| Teicoplanin | 0.5 | 0.5 | 0.5 | 0.5 | 1 | 1 | 4 | 8 | 4 | 4 | 1 | 16 |
| Oritavancin | 0.25 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.5 | 0.25 | 0.5 | 1 | 0.5 | 0.5 |
| Linezolid | 2 | 2 | 4 | 2 | 4 | 2 | 2 | 2 | 2 | 2 | 4 | 1 |
| Ranbezolid | 2 | 2 | 4 | 2 | 4 | 4 | 0.125 | 0.125 | 0.25 | 0.125 | 2 | 0.125 |
| Daptomycin | 0.5 | 0.5 | 1 | 2 | 1 | 1 | 0.5 | 0.25 | 0.125 | 0.25 | 0.5 | 0.5 |
| Tigecycline | 0.5 | 0.5 | 0.5 | 0.5 | 1 | 0.5 | 0.25 | 0.25 | 1 | 1 | 0.5 | 0.5 |
| Quinupristin-dalfopristin | 0.25 | 0.5 | 0.5 | 0.5 | 0.5 | 1 | 0.125 | 0.125 | 0.125 | 0.25 | 1 | 0.25 |
a
Strains SA8, SA9, and SA12, methicillin-susceptible S. aureus; strains SA13, SA16, and SA19, methicillin-resistant S. aureus; strains CN3, CN6, and CN20 methicillin-susceptible coagulase-negative staphylococci; strains CN5, CN11, and CN18 methicillin-resistant coagulase-negative staphylococci.