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. 2004 Oct;48(10):3720–3728. doi: 10.1128/AAC.48.10.3720-3728.2004

TABLE 6.

Clinical features and outcomes of bloodstream infections due to CMY-1-related AmpC β-lactamase-producing K. pneumoniae isolatesa

Isolate no. Age (yr)/sex Underlying disease Comorbid condition Type or site of infection Empirical therapy Definitive therapy Outcome
26 73/M CBD stone None Cholangitis CTX, AMK CTX, AMK Cured with biliary decompression and antimicrobial therapy
29 55/M CBD cancer Post-ERCP Cholangitis CAZ, CIP CTX, CIP Death on day 15 of treatment
32 63/M CBD stone Post-EST Cholangitis CIP, AMK CIP, AMK Cured with antimicrobial therapy
33 65/M CBD stone Post-EST Cholangitis CIP, AMK CIP, AMK Cured with biliary decompression
34 50/F Pancreas cancer None Cholangitis CTX, AMK CTX, AMK Cured with antimicrobial therapy
44 57/M IHD stone, DM Liver segmentectomy Abdominal abscess IPM IPM Cured with drainage and antimicrobial therapy
45 54/F IHD stone None Cholangitis CTX, CIP CIP Cured with antimicrobial therapy
48 56/M GB cancer None Cholangitis CAZ, AMK IPM Persistent fever after 3 days; treatment changed to imipenem, with cure
51 28/M Wilson's disease Liver transplantation Liver abscess CTX IPM Cured with drainage and antimicrobial therapy
52 49/M Liver cirrhosis with biliary obstruction Post-PTBD Cholangitis CTX, AMK IPM, AMK Persistent fever after 2 days; treatment changed to imipenem and biliary decompression, cure
53 62/M CBD cancer Post-ERCP Cholangitis CIP, AMK IPM Persistent fever after 3 days; treatment changed to imipenem and biliary decompression, cured
54 45/F Liver cirrhosis, HCC Foley catheter Peritonitis CTX, AMK CTX, AMK Death on day 3 of treatment
59 68/F Periampullary cancer Post-ERCP Cholangitis CTX, AMK IPM Persistent fever after 5 days; treatment changed to imipenem, with cure
61 61/M Liver cirrhosis, HCC None Unknown CTX, AMK IPM Persistent fever after 2 days; treatment changed to imipenem, with cure
a

Abbreviations: M, male; F, female; GB, gall bladder; IHD, intrahepatic duct; CBD, common bile duct; EST, endoscopic sphincterotomy; ERCP, endoscopic retrograde cholangiopancreaticography; PTBD, percutaneous transhepatic biliary drainage; DM, diabetes mellitus; ESRD, end-stage renal disease; HCC, hepatocellualr carcinoma; CTX, cefotaxime; CAZ, ceftazidime; AMK, amikacin; CIP, ciprofloxacin; IPM, imipenem.