TABLE 1.
MOI dependence of benzimidazole nucleosides and GCV
| Compound | IC90 (μM) in yield reduction assay at the following MOIs (PFU/cell)a:
|
|||
|---|---|---|---|---|
| 0.001 | 0.01 | 0.1 | 1.0 | |
| 853 | NDb | 5.9 ± 0.6 | 9.2 ± 0.9 | 5.8 ± 1.2 |
| 1049 | ND | 0.41 ± 0.14 | 0.46 ± 0.19 | 0.50 ± 0.14 |
| 1311 | 0.77 ± 0.40 | 1.7 ± 0.6 | 6.6 ± 1.0 | 52 ± 5 |
| GCV | 4.0 ± 1.9 | 3.2 ± 0.6 | 2.4 ± 0.7 | 4.4 ± 3.8 |
| Maribavir | ND | 0.11 ± 0.03 | 0.49 ± 0.12 | 1.2 ± 0.14 |
| BDCRB | 0.41 ± 0.08 | 0.45 ± 0.05 | 0.31 ± 0.02 | 0.48 ± 0.10 |
a
Inhibition of infectious HCMV (Towne strain) titer production was measured at eight drug concentrations ranging from 100 to 0.05 μM. Data are presented as the means±SDs of IC90s determined in quadruplicate.
b
ND, not determined.