TABLE 4.
Effect of UV-inactivated HCMV on the antiviral potency of selected compounds
| Compound | IC90 (μM) in yield reduction assay in the presence of UV-inactivated virus (PFU/cell)a
|
|||
|---|---|---|---|---|
| None | 0.0025 | 0.025 | 0.25 | |
| 1028 | 0.27 ± 0.24 | 0.25 ± 0.12 | 0.64 ± 0.63 | 0.32 ± 0.24 |
| 1311 | 0.34 ± 0.06 | 0.47 ± 0.05 | 0.34 ± 0.02 | 0.30 ± 0.15 |
| 1369 | 0.010 ± 0.001 | 0.013 ± 0.001 | 0.014 ± 0.003 | 0.019 ± 0.008 |
| Maribavir | 0.12 ± 0.02 | 0.08 ± 0.02 | 0.11 ± 0.02 | 0.11 ± 0.05 |
| GCV | 2.0 ± 0.4 | 1.5 ± 0.4 | 2.1 ± 0.2 | 3.0 ± 0.1 |
| BDCRB | 0.11 ± 0.03 | 0.11 ± 0.01 | 0.10 ± 0.04 | 0.11 ± 0.02 |
a
Inhibition of viral titer production in HFF infected with HCMV Towne strain (0.005 PFU/cell) in the presence of the indicated amounts of UV-inactivated virus. Yields were measured at eight drug concentrations from 120 to 0.02 μM. IC90s are reported as the means ± SDs of three experiments.