. 2004 Oct;48(10):3928–3933. doi: 10.1128/AAC.48.10.3928-3933.2004

TABLE 2.

Daptomycin monotherapy compared to ceftriaxone plus vancomycin therapy against penicillin-resistant S. pneumoniae WB4 and a penicillin- and quinolone-resistant mutant in experimental meningitis

Strain and antibiotic treatment (infecting strain susceptibility)^a	n	Mean initial titer ± SD (log₁₀ CFU/ml)	Mean killing rate ± SD (Δlog₁₀ CFU/ml · h)	Mean killing rate/8 h ± SD (log₁₀ CFU/ml)
S. pneumoniae WB4 (Pen^r)
None (controls) (Pen^r)	10	6.75 ± 0.30	+0.04 ± 0.06	+0.40 ± 0.42
Daptomycin, 15 mg/kg (Pen^r)	10	6.95 ± 0.85	−1.20 ± 0.32^b	−6.95 ± 0.85^b
Ceftriaxone + vancomycin (Pen^r)	10	6.25 ± 0.45	−0.45 ± 0.12^c	−3.45 ± 0.76^c
S. pneumoniae WB4 mutant
None (controls) (Pen^r, Qu^r)	10	5.39 ± 1.0	+0.20 ± 0.19	+1.31 ± 0.87
Daptomycin, 15 mg/kg (Pen^r, Qu^r)	10	6.01 ± 0.34	−0.97 ± 0.32^c	−6.01 ± 0.34^d ^e
Daptomycin, 20 mg/kg (Pen^r, Qu^r)	10	6.22 ± 0.23	−0.91 ± 0.08^c	−6.22 ± 0.23^d ^e
Ceftriaxone + vancomycin (Pen^r, Qu^r)	10	5.79 ± 0.64	−0.63 ± 0.13^c	−5.02 ± 1.11^d ^e

Pen^r, penicillin resistant; Qu^r, quinolone resistant.

P < 0.01, daptomycin versus ceftriaxone plus vancomycin.

P < 0.01, daptomycin (15 and 20 mg/kg) versus ceftriaxone plus vancomycin.

P > 0.05, difference between daptomycin 20 versus 15 mg/kg not significant.