Table 3.
Antioxidant/oxidant parameters in patients with Bloom syndrome (BS).
| Antioxidant/oxidant parameter | Parameter changes | Biological material | Method | number of patients (n) | Refs. |
|---|---|---|---|---|---|
| Lipophilic antioxidants | |||||
| α-tocopherol | ≈ | plasma | HPLC | 4 | [62] |
| ≈ | HPLC | 4 | [53] | ||
| γ-tocopherol | ≈ | plasma | HPLC | 4 | [62] |
| ≈ | HPLC | 4 | [53] | ||
| Other non-enzymatic antioxidants | |||||
| Oxidised glutathione (GSSG) | ↓ | whole blood | HPLC | 4 | [62] |
| GSSG: GSH ratio | ↓ | whole blood | HPLC | 4 | [62] |
| ↓ | whole blood | HPLC | 4 | [53] | |
| Glyoxal (Glx) | ≈ | plasma | HPLC | 4 | [62] |
| ≈ | HPLC | 4 | [53] | ||
| Methylglyoxal (MGlx) | ≈ | plasma | HPLC | 4 | [62] |
| ≈ | HPLC | 4 | [53] | ||
| Uric acid (UA) | ↑ | plasma | HPLC | 4 | [53] |
| ↑ | HPLC | 4 | [62] | ||
| Ascorbic acid (AA) | ≈ | plasma | HPLC | 4 | [62] |
| ≈ | HPLC | 4 | [53] | ||
| Oxidative modifications products | |||||
| 8-hydroxy−2-deoxyguanosine (8-OHdG) | ↑ | leukocytes | LC | 4 | [62] |
| ↑ | LC | 4 | [53] | ||
| ≈ | urine | LC | 4 | [62] | |
| ↑ | LC | 4 | [53] | ||
Abbreviations: ↑ - statistically significant increase vs control, ↓ - statistically significant decrease vs control, ≈- changes not statistically significant vs control, HPLC - High-Performance Liquid Chromatography, LC - Liquid Chromatography.