Table 1.
Inhibitory concentration 50 (IC50) of all reference drugs against T. copemani G1 and G2, and T. cruzi, and toxicity against L6 cells. Values are in μM. SD: standard deviation.
| Compounds |
T. copemani G1 (IC50 ± SD) |
T. copemani G2 (IC50 ± SD) |
T. cruzi (IC50 ± SD) |
Toxicity on L6 cells (IC50 ± SD) |
|---|---|---|---|---|
| Benznidazole | 1.053 ± 0.183 (>94.9) |
0.713 ± 0.186 (>140.2) |
8.537 ± 0.306 (>11.7) |
>100 μM |
| Posaconazole | 1.254 ± 0.418 (>79.7) |
6.147 ± 0.154 (>12.3) |
5.429 ± 0.151 (>18.4) |
>100 μM |
| Melarsoprol | 0.007 ± 0.001 (8.8) |
0.005 ± 0.0006 (12.1) |
0.010 ± 0.001 (6.2) |
0.062 μM |
| Miltefosine | 0.095 ± 0.007 (2.4) |
0.745 ± 0.034 (0.31) |
2.109 ± 0.112 (0.1) |
0.231 μM |
| Podophyllotoxina | – | – | – | 0.01 μM |
() Therapeutic indices are given in parenthesis.
a
Reference drug for toxicity.