Table 2.
Inhibitory concentration 50 (IC50) of lead compounds against T. copemani G1 and G2, and T. cruzi, and toxicity against L6 cells. Values are in μM. SD: standard deviation.
| Compounds |
T. copemani G1 (IC50 ± SD) |
T. copemani G2 (IC50 ± SD) |
T. cruzi (IC50 ± SD) |
Toxicity on L6 cells (IC50 ± SD) |
|---|---|---|---|---|
| FN1 | 3.316 ± 0.1021 (>30.1) |
2.395 ± 0.302 (>41.7) |
6.112 ± 0.0655 (>16.4) |
>100 μM |
| FN2 | 1.122 ± 0.3971 (53.1) |
0.969 ± 0.188 (61.4) |
5.979 ± 0.2281 (10) |
59.52 μM |
| PDB1 | 2.675 ± 0.7263 (>37.4) |
7.178 ± 0.713 (>14) |
5.261 ± 0.6828 (>19) |
>100 μM |
| PDB2 | 1.51 ± 0.2736 (33.1) |
3.343 ± 0.197 (15) |
4.533 ± 0.3151 (11) |
50.06 μM |
| Podophyllotixina | – | – | – | 0.01 μM |
() Therapeutic indices are given in parenthesis.
a
Reference drug for toxicity.