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. 2017 Jan 7;36:7. doi: 10.1186/s13046-016-0481-1

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — PFK15 suppresses the glycolytic activity of HNSCC cells. a Molecular structure of 1-(4-pyridinyl)-3-(2-quinolinyl)-2-propen-1-one (PFK15). b Cell growth determined by MTT assays in Cal27 cells after PFK15 treatment. c Measurement of fructose 2,6-bisphosphate (F26BP) in Cal27 cells after PFK15 treatment. d Glucose uptake was analyzed in Cal27 cells using 2-NBDG. e Lactate productionof Cal27 cells treated with PFK15 were detected. f ATP generation inside of the Cal27 cells treated with PFK15 were measured. Mean ± S.E.M.; *P < 0.05, **P < 0.01, ***P < 0.001