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. 2017 Jan 7;8:1. doi: 10.1186/s13293-016-0124-4

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 9 — Sex-dependent alteration of cardiac cytochrome CYP gene expression by doxorubicin. Doxorubicin causes male-specific induction of Cyp1b1 gene expression. Cyp1b1 enzyme is known to generate cardiotoxic metabolites such as mid-chain hydroxyeicosatetraenoic acids (HETEs) and/or 6β-hydroxytestosterone. On the other hand, DOX causes female-specific induction of Cyp2c29 and Cyp2e1 gene expression. Cyp2c29 and Cyp2e1 enzymes are known to generate cardioprotective metabolites such as epoxyeicosatrienoic acids (EETs) and 19-hydroxyeicosatetraenoic acid (19-HETE)