Table 2.

Univariate and multiple Cox proportional hazard analysis between clinical and pathological variables with PTC recurrence

	Univariate		Multivariate
Variables	HR(95%CI)	P value	HR(95%CI)	P value
ATA risk
Low × high	1.67(0.38–7.64)	0.389
Low × intermediate	0.87(0.29–3.35)	0.879
Intermediate × high	3.34(1.42–6.75)	0.087
MSKCC–NY risk
Low × high	1.67(0.77–3.98)	0.196
Low × intermediate	2.12(0.78–5.86)	0.132
Intermediate × high	1.45(0.52–3.88)	0.243
Primary tumor size	5.14(3.14–11.64)	0.009*	1.54(0.43–7.67)	0.567
TNM stage
I/II × III/IV	4.31(2.01–9.87)	0.011*	2.68(1.10–6.72)	0.067
Extrathyroid extension	2.12(0.78–6.81)	0.021*	2.53(0.54–12.42)	0.314
Cervical lymph node metastasis	2.85(0.76–6.12)	0.107
miR-21	2.01(0.33–5.43)	0.132
miR-9	1.32(0.54–4.53)	0.225
miR-146b	1.11(0.24–4.13)	0.682
miR-220	1.13(0.45–4.14)	0.745
miR-221	1.46(1.20–1.88)	0.001*	1.41(1.14–1.95)	0.007*
miR-222	2.81(1.11–7.21)	0.021*	1.86(0.76–5.65)	0.226

PTC, papillary thyroid cancer, ATA American Thyroid Association, MSKCC–NY Memorial Sloan Kettering Cancer Center, CI confidence interval, HR hazard ratio

*P value <0.05