Table 3.
Values of the inflammatory, hemostatic and endothelial biomarkers measured in this study in normal weight and overweight/obese dogs
| Parameter/unit | Normal weight | Dogs | Overweight | And obese dogs | R and P -value |
|---|---|---|---|---|---|
| Mean ± SEM | Median; CI (P 25–P 75) | Mean ± SEM | Median; CI (P 25–P 75) | ||
| sICAM-1 μg/ml | 320 ±13 | 321; 275–356 | 329 ± 8.2 | 326; 288–361 | 9.021; pd 0.536 |
| IL–6 pg/ml | 227 ± 8.9 | 220; 197–256 | 261 ± 4.9 | 259; 235–287 | 34.829; pd 0.001 ** |
| HMGB-1 ng/ml | 85 ± 4.5 | 83; 70–93 | 89 ± 2.6 | 89; 76–98 | 4.343; pd 0.384 |
| hsCRP μg/ml | 3.7 ± 0.17 | 3.7; 3.2–4.3 | 4.2 ± 0.14 | 3.9; 3.6–4.7 | 0.502; pd 0.027 * |
| suPAR pg/ml | 2598 ± 136 | 2559; 2195–2923 | 1990 ± 126 | 1869; 1542–2486 | −608.314; pd 0.002 * |
| PAI-1 ng/ml | 70 ± 5.9 | 61; 44–94 | 75 ± 6.9 | 70; 43–86 | 1.145; np 0.611 |
| FIB g/L | 2.6 ± 0.16 | 2.6; 2.0–3.0 | 3.0 ± 0.20 | 2.6; 2.2–3.5 | 1.312; np 0.185 |
| FIX % | 96 ± 5.6 | 93; 77–106 | 112 ± 6.8 | 100; 84–140 | 1.385; np 0.081 |
| FVII % | 109 ± 6.2 | 110; 82–136 | 131 ± 8.7 | 125; 100–147 | 1.492; pd 0.054 * |
| FX % | 104 ± 2.2 | 106; 94–112 | 115 ± 2.9 | 110; 102–128 | 11.557; pd 0.007 ** |
| PT sec | 6.1 ± 0.04 | 6.1; 6.0–6.2 | 6.1 ± 0.04 | 6.1 6.0–6.2 | 0.989; np 0.580 |
| aPTT sec | 11 ± 0.23 | 11; 10–12 | 10 ± 0.20 | 10; 9.3–11 | −0.749; pd 0.022 * |
| MPV fl | 8.3 ± 0.14 | 8; 8–9 | 8.6 ± 0.17 | 8; 8–9 | 0.318; pd 0.169 |
| PLT x109/L | 234 ± 13 | 228; 201–265 | 315 ± 18 | 298; 253–401 | 80.916; pd 0.001 ** |
HMGB-1 high mobility group box – 1 protein, sICAM-1 soluble intercellular adhesive molecule -1, IL-6 interleukin – 6, hsCRP high sensitivity C reactive protein, PAI-1 plasminogen activator inhibitor type 1, suPAR soluble plasminogen activator receptor, FIB fibrinogen, FX, FIX, FVII clotting factors X, IX and VII, PT prothrombine time, aPTT activated partial thromboplastine time, MPV mean platelet volume, PLT number of platelets, np nonparametric distribution, pd parametric distribution
*p ≤ 0.05, **p < 0.01,