Table 1.
Clinicopathologic Characteristics of three groups according to Ki67-LI level
| Characteristic | Ki67 ≤ 10% n = 342 |
10% < Ki67 < 30% n = 281 |
Ki67 ≥ 30% n = 316 |
Total N = 939 |
P value |
|---|---|---|---|---|---|
| Associated events-no.(%) | 10(2.9) | 20(7.1) | 49(15.5) | 79(8.4) | |
| Age | |||||
| Median(IQT)-yr | 49(23–86) | 48(24–91) | 47(22–84) | 48(22–91) | 0.166 |
| Distribution-no.(%) | 0.013 | ||||
| < 35 | 19(5.6) | 15(5.3) | 31(9.8) | 65(6.9) | |
| 35–50 | 160(46.8) | 148(52.7) | 163(51.6) | 471(50.2) | |
| 51–65 | 122(35.7) | 93(33.1) | 102(32.3) | 317(33.8) | |
| > 65 | 41(12.0) | 25(8.9) | 20(6.3) | 86(9.2) | |
| Menopausal status-no.(%) | 0.011 | ||||
| Pre | 171(50.0) | 122(43.4) | 176(55.7) | 469(49.9) | |
| Post/Peri | 171(50.0) | 159(56.6) | 140(44.3) | 470(50.0) | |
| Histology-no.(%) | <0.001 | ||||
| IDC | 273(79.8) | 236(84.0) | 297(94.0) | 806(85.8) | |
| ILC | 10(2.9) | 10(3.6) | 6(1.9) | 26(2.8) | |
| Mucinous | 25(7.3) | 13(4.6) | 4(1.3) | 42(4.5) | |
| Other invasive histology | 34(9.9) | 22(7.8) | 9(2.8) | 65(6.9) | |
| pT-no./total no.(%) | <0.001 | ||||
| 1 | 239/336(71.1) | 181/276(65.6) | 159/307(51.8) | 579/919(63.0) | |
| 2 | 91/336(27.1) | 86/276(31.2) | 139/307(45.3) | 316/919(34.4) | |
| 3 | 6/336(1.8) | 9/276(3.3) | 9/307(2.9) | 24/919(2.6) | |
| Node-no.(%) | 0.022 | ||||
| N0 | 249(72.8) | 180(64.1) | 202(63.9) | 631(67.2) | |
| N1 | 93(27.2) | 101(35.9) | 114(36.1) | 308(32.8) | |
| LVI-no.(%) | 0.074 | ||||
| Positive | 49(14.3) | 59(21.0) | 61(19.3) | 169(18.0) | |
| Negative | 293(85.7) | 222(79.0) | 255(80.7) | 770(82.0) | |
| Grade-no./total no.(%) | <0.001 | ||||
| I/II | 269/289(93.1) | 189/241(78.4) | 137/282(48.6) | 595/812(73.3) | |
| III | 20/289(6.9) | 52/241(21.6) | 145/282(51.4) | 217/812(26.7) | |
| PgR-no.(%) | <0.001 | ||||
| < 20% | 58(17.0) | 55(19.6) | 119(37.7) | 232(24.7) | |
| ≥ 20% | 284(83.0) | 226(80.4) | 197(62.3) | 707(75.3) | |
| Surgery-no.(%) | 0.479 | ||||
| BCS | 202(59.1) | 178(63.3) | 187(59.2) | 567(60.4) | |
| Mastectomy | 140(40.9) | 103(36.7) | 129(40.8) | 372(39.6) | |
| Chemotherapy-no.(%) | <0.001 | ||||
| Yes | 252(73.7) | 234(83.3) | 290(91.8) | 776(82.6) | |
| No | 90(26.3) | 47(16.7) | 26(8.2) | 163(17.4) | |
| Radiotherapy-no.(%) | 0.033 | ||||
| Yes | 237(69.3) | 217(77.2) | 243(76.9) | 697(74.2) | |
| No | 105(30.7) | 64(22.8) | 73(23.1) | 242(25.8) |
IQT interquartile range, IDC invasive ductal carcinoma, ILC invasive lobular carcinoma, LVI lymphovascular invasion, PgR progesterone receptor, BCS breast-conserving surgery