Fig. 2.

A similar trend in intolerance can be observed across LDLR using sequence- and structure-based prediction algorithms, i.e. sequence-based methods tend to agree on intolerance given that they both rely on sequence conservation whereas structure-based algorithms utilize the additional structure-based properties made available to them to show a different tolerance profile. Unlike HOXA5, genome-wide prediction algorithms appear to agree on potential peaks of intolerance across the non-coding region of LDLR