Table 1.
List of in silico prediction algorithms and conservation scores summarized through the Genome Tolerance Browser
| Non-Synonymous Prediction Algorithms | |
|---|---|
| Generic | Cancer-Specific |
| SIFT | TransFIC (SIFT) |
| PolyPhen-2 (HumVar & HumDiv) | TransFIC (PolyPhen-2) |
| MutationAssessor | TransFIC (MutationAssessor) |
| FATHMM (Unweighted & Weighted) | FATHMM (Cancer) |
| FATHMM-MKL (Coding) | |
| MutationTaster2 | |
| PROVEAN | |
| VEST | |
| LRT | |
| MetaLR | |
| MetaSVM | |
| Genome-Wide Prediction Algorithms | |
| CADD | |
| DANN | |
| FATHMM-MKL (Non-coding) | |
| fitCons | |
| Conservation Scores | |
| PhastCons (46-Way) | |
| PhyloP (46-way; vertebrate, primates and placental mammals) | |
| PhastCons (100-Way) | |
| PhyloP (100-way; vertebrate, primates and placental mammals) | |
| GERP++ | |
| SiPhy | |