Table 2.
Cox regression coefficients (95% confidence intervals) associated with CVD mortality for each risk factor included in the five-year CVD mortality risk prediction algorithms
| Variable (reference group/units) | Primary model | Low information model | Traditional risk factor model |
|---|---|---|---|
| Age | 0.373 (0.307, 0.438) | 0.310 (0.242, 0.379) | 0.168 (0.158, 0.178) |
| Sex (men) | −1.066 (−1.659, −0.473) | −2.438 (−3.773, −1.103) | −0.535 (−0.655, −0.412) |
| Systolic blood pressure (10 mmHg) | 0.941 (0.653, 1.230) | 0.790 (0.490, 1.090) | 0.114 (0.088, 0.140) |
| Total serum cholesterol (mmol/L) | 0.122 (0.071, 0.172) | 0.140 (0.091, 0.188) | |
| HDL-cholesterol (mmol/L) | −0.482 (−0.794, −0.170) | −0.238 (−0.433, −0.043) | |
| Diabetes (no diabetes) | 0.071 (−0.174, 0.316) | 0.437 (0.256, 0.617) | 0.443 (0.260, 0.625) |
| Smoker (not current) | 2.903 (1.549, 4.257) | 3.944 (2.530, 5.358) | 0.768 (0.628, 0.907) |
| SEIFA fifth (most disadvantaged) | −0.119 (−0.174, −0.064) | −0.095 (−0.148, −0.043) | |
| eGFR (ml/min/m2) | −0.127 (−0.165, −0.088) | ||
| eGFR2 (ml/min/m2)2 | 0.0009 (0.0007, 0.0012) | ||
| Interactions | |||
| sex X diabetes | 0.424 (0.041, 0.807) | ||
| sex X SEIFA | −0.115 (−0.198, −0.032) | −0.135 (−0.215, −0.055) | |
| sex X HDL-cholesterol | 0.504 (0.114, 0.895) | ||
| age X systolic blood pressure | −0.013 (−0.017, −0.008) | −0.010 (−0.015, −0.006) | |
| age X smoker | −0.035 (−0.056, −0.014) | −0.050 (−0.072, −0.028) | |
| age X sex | 0.034 (0.014, 0.054) | ||