Table 2.
Biochemical parameters and echocardiogram findings
| Variable | 2010 (n = 804) |
2011 (n = 930) |
2012 (n = 1045) |
2013 (n = 1241) |
2014 (n = 1268) |
P |
|---|---|---|---|---|---|---|
| Biochemical | ||||||
| TC (mmol/L) | 4.54 ± 1.26 | 4.48 ± 1.16 | 4.44 ± 1.35 | 4.42 ± 1.19 | 4.35 ± 1.26 | 0.020 |
| TG (mmol/L) | 3.12 ± 6.26 | 2.23 ± 1.51 | 2.28 ± 1.88 | 2.31 ± 1.89 | 2.49 ± 6.83 | 0.026 |
| LDL (mmol/L) | 3.21 ± 8.39 | 2.26 ± 0.96 | 2.75 ± 1.09 | 2.74 ± 1.01 | 2.77 ± 3.26 | NS |
| HDL (mmol/L) | 0.99 ± 0.22 | 0.94 ± 0.23 | 0.91 ± 0.21 | 0.89 ± 0.21 | 0.89 ± 0.20 | 0.000 |
| Creatinine (mg/dL) | 82.59 ± 34.06 | 78.41 ± 16.91 | 78.83 ± 47.32 | 77.85 ± 45.99 | 77.79 ± 18.38 | 0.030 |
| BUN (mmol/L) | 7.61 ± 4.85 | 7.29 ± 4.55 | 7.66 ± 5.17 | 7.51 ± 4.54 | 7.18 ± 4.53 | NS |
| UA (μmol/L) | 372.1 ± 111.2 | 355.5 ± 88.9 | 359.9 ± 91.3 | 367.9 ± 93.4 | 380.4 ± 91.9 | 0.000 |
| ALT (U/L) | 50.2 ± 48.3 | 45.4 ± 35.2 | 48.6 ± 43.1 | 46.8 ± 41.4 | 48.1 ± 42.0 | NS |
| AST (U/L) | 62.3 ± 92.7 | 56.7 ± 89.5 | 52.2 ± 77.2 | 51.2 ± 74.3 | 53.1 ± 77.4 | NS |
| CK (U/L) | 386.9 ± 875.3 | 368.3 ± 894.6 | 314.4 ± 737.5 | 336.8 ± 718.7 | 377.7 ± 928.1 | NS |
| CKMB (ng/ml) | 33.7 ± 76.1 | 29.4 ± 82.1 | 20.8 ± 60.5 | 26.0 ± 138.1 | 29.5 ± 141.3 | NS |
| cTnT (ng/ml) | 1.94 ± 1.43 | 1.82 ± 1.31 | 1.87 ± 1.53 | 1.97 ± 2.23 | 1.95 ± 1.97 | NS |
| NT-proBNP (pg/ml) | 657.0 ± 3973.8 | 385.6 ± 1348.7 | 372.8 ± 1638.5 | 206.8 ± 572.4 | 197.0 ± 561.7 | 0.000 |
| Glucose (mmol/L) | 6.73 ± 2.89 | 6.45 ± 2.51 | 6.57 ± 2.71 | 6.67 ± 2.68 | 6.56 ± 2.88 | NS |
| HbA1c (%) | 6.86 ± 1.76 | 6.64 ± 1.72 | 6.71 ± 1.71 | 6.16 ± 1.70 | 6.36 ± 1.63 | NS |
| CRP (mg/dl) | 5.22 ± 1.13 | 4.28 ± 1.28 | 4.43 ± 1.56 | 3.54 ± 1.25 | 3.38 ± 0.98 | 0.000 |
| Hematologic | ||||||
| Hemoglobin (g/L) | 147.4 ± 16.2 | 147.5 ± 15.3 | 146.2 ± 15.6 | 146.8 ± 16.0 | 147.6 ± 15.0 | NS |
| Red cell count (10*12/L) | 5.90 ± 1.89 | 5.91 ± 1.92 | 6.00 ± 1.91 | 6.15 ± 1.94 | 6.09 ± 1.99 | 0.017 |
| White cell count (10*9/L) | 9.20 ± 3.69 | 8.57 ± 2.99 | 8.41 ± 3.08 | 8.59 ± 3.34 | 8.74 ± 3.36 | 0.005 |
| Platelet count | 230.9 ± 72.7 | 228.8 ± 5.96 | 225.6 ± 58.8 | 233.8 ± 58.2 | 236.1 ± 64.2 | NS |
| RDW (%) | 12.96 ± 0.69 | 13.03 ± 0.62 | 12.80 ± 0.71 | 12.71 ± 0.79 | 12.91 ± 1.28 | 0.018 |
| Echocardiography | ||||||
| LVDd (mm) | 50.28 ± 5.38 | 49.64 ± 5.27 | 49.87 ± 5.84 | 49.92 ± 5.71 | 49.42 ± 5.44 | 0.028 |
| IVST (mm) | 10.07 ± 1.53 | 10.21 ± 1.51 | 10.13 ± 1.59 | 10.32 ± 1.58 | 10.05 ± 1.60 | 0.002 |
| EF (%) | 59.3 ± 9.2 | 59.8 ± 8.9 | 59.8 ± 9.5 | 59.8 ± 9.1 | 59.8 ± 9.0 | NS |
Abbreviations: TC total cholesterol, TG triglyeride, LDL low density lipoprotein cholesterol, HDL high density lipoprotein cholesterol, Cr creatinine, BUN blood urea nitrogen, UA uric acid, ALT alanine aminotransferase, AST Aspartate transaminase, CK creatine kinase, CKMB creatine kinase MB isoenzyme, cTnT cardiac Troponin T, NT-proBNP N-terminal pro-B-type natriuretic peptide, HbA1c hemoglobin A1c, LVDd left ventricular end-diastolic dimension, IVST interventricular septal thickness, EF ejection fraction