Table 1. Transgenes, PrP^C expression patterns, and anti-PrP^C responses in mice immunized with PrP^REC.

Mouse line	Construct	Main site of PrP expression	Thymic transcription*	Anti-native PrPC response, log10 at day 28	T cell response, proliferation index
ZH-I	Prnpo/o	None	Undetectable	3–4	3.2 ± 1.68
WT	C57BL/6	Ubiquitous	100 ± 15.9	0–1	1 ± 0.12
Tg33	Lck-Prp	T cells	7,705 ± 428	0–1	0.42†
Tg306	CD19-PrP	B cells	Not done	0–1	0.35†
Tg01	Alb-PrP	Hepatocytes	1.5 ± 0.1	0–1	1.23†
Tg1152	NSE-PrP	Neurons	28.9 ± 6	0–1	0.87†
Tg640	MBP-PrP	Oligodendrocytes and Schwann cells	5.5 ± 1.3	2–3	1.3 ± 0.58

^*Relative to WT transcription (arbitrarily set to 100)

^†n = 2