Table 3.
Summary of clinical changes over time (n = 20).
| Ocular measurement | Baseline | 2 weeks | 1 month | 3 month | p-Value |
|---|---|---|---|---|---|
| Parametric (mean ± SD) | |||||
| OSDI | 44.8 ± 17.0 | 25.0 ± 15.6* | 23.4 ± 15.1* | 23.6 ± 17.9* | <0.01 |
| SANDE Global Score | 63.0 ± 20.6 | 52.8 ± 23.2* | 41.6 ± 27.3* | 30.6 ± 25.1* | <0.01 |
| Eyelid margin score | 6.0 ± 3.1 | N/A | 5.6 ± 2.7 | 4.9 ± 2.6* | 0.02 |
| LLT | 82.2 ± 15.4 | N/A | 76.6 ± 15.9 | 79.5 ± 16.7 | 0.21 |
| Osmolarity | 301 ± 13 | N/A | 304 ± 11 | 302 ± 11 | 0.35 |
| Non-parametric (Q1, median, Q3) | |||||
| NIBUTa | 1.75, 2.42, 3.27 | N/A | 1.97, 3.05, 4.49* | 2.22, 2.90, 3.63* | 0.02 |
| Meibum qualitya | 2.0, 2.5, 3.0 | N/A | 2.0, 2.0, 2.0 | 1.0, 1.5, 2.0* | <0.01 |
| Expressibilitya | 2.0, 2.0, 3.0 | N/A | 1.0, 2.0, 2.0 | 1.0, 2.0, 2.0* | <0.01 |
| Number of glands blockeda | 5.3, 6.0, 7.0 | N/A | 2.3, 4.0, 6.0* | 1.0, 2.0, 4.8* | <0.01 |
| Schirmer's testa | 4.5, 8.5, 14.0 | N/A | 4.0, 9.0, 13.0 | 5.3, 11.0, 25.0 | 0.41 |
| Meniscus Heighta | 0.17, 0.20, 0.26 | N/A | 0.16, 0.19, 0.27 | 0.18, 0.22, 0.24 | 0.78 |
| LWEa | 0.00, 0.00, 0.19 | N/A | 0.00, 0.00, 0.75 | 0.00, 0.00, 0.50 | 0.29 |
| Corneal Staininga | 14, 53, 96 | N/A | 5, 40, 124 | 3, 25, 46 | 0.36 |
| Conjunctival Staininga | 0.2, 1.0, 2.0 | N/A | 0.0, 1.0, 1.0 | 0.0, 1.0, 1.0 | 0.08 |
| Meibographya | 0.2, 2.0, 4.0 | N/A | 1.0, 2.0, 3.8 | 1.0, 2.0, 4.0 | 0.66 |
a
Friedman test.
*
p < 0.05 from baseline.