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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Cancer Prev Res (Phila). 2016 Nov 2;10(1):55–66. doi: 10.1158/1940-6207.CAPR-16-0117

Figure 3.

Figure 3

A) Lineage tracing of BE metaplasia at the SCJ in pL-IL-1β mice crossed to Lgr5CreTM mice and Confetti reporter mice at the age of 12 months, 9 months after Tamoxifen treatment; white arrows show lineage of red and green clones in BE tissue and red arrows show single Lgr5-GFP positive cells in BE tissue. B) Histopathologcial score in correlation with Lgr5-GFP positive cells at the SCJ in the pL2-IL-1β mouse model (ANOVA p<0.0001, R square 0.8418, F 49.65). C) Representative LGR5 staining of human biopsies from BE or adjacent to EAC tissue. D) LGR5 staining in human biopsies from BE or adjacent to EAC tissue was scored from 0 to 3; percentage of each score in both groups is shown (35/41/12/12% in BE as well as 25/18/16/41% in EAC).