Table 2.
Top Principal Discharge Diagnoses for Hospitalizations with a Secondary Diagnosis of Granulomatosis with Polyangiitis
| Principal Diagnosis | 1993 | 1994 | 1995 | 1996 | 1997 | 1998 | 1999 | 2000 | 2001 | 2002 | 2003 | 2004 | 2005 | 2006 | 2007 | 2008 | 2009 | 2010 | 2011 | P-for- Trend |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| All Secondary GPA Hospitalizations | ||||||||||||||||||||
| Total Infection | 31.0% | 27.3% | 27.5% | 26.3% | 26.0% | 22.1% | 21.6% | 23.6% | 23.4% | 23.1% | 23.1% | 21.5% | 24.4% | 22.7% | 27.2% | 24.2% | 26.9% | 24.6% | 26.6% | 0.97 |
| Infectious and parasitic diseases | 6.1% | 6.6% | 6.3% | 6.0% | 5.7% | 4.5% | 3.5% | 4.8% | 4.4% | 3.8% | 4.1% | 4.8% | 5.5% | 6.5% | 6.6% | 6.3% | 7.4% | 6.8% | 8.2% | <0.0001 |
| Respiratory infection | 16.4% | 11.3% | 14.1% | 14.0% | 14.1% | 10.3% | 11.7% | 11.9% | 10.9% | 11.4% | 10.7% | 9.3% | 11.9% | 9.0% | 11.8% | 10.3% | 10.6% | 9.6% | 10.2% | <0.0001 |
| Diseases of Respiratory System (Including Infection) | 23.9% | 20.8% | 25% | 23.4% | 24.7% | 18.4% | 20.0% | 21.9% | 21.5% | 22.1% | 21.0% | 20.5% | 24.2% | 21.5% | 22.7% | 22.9% | 21.3% | 20.2% | 22.7% | 0.6 |
| Neoplasm | 4.6% | 3.5% | 3.8% | 5.5% | 2.5% | 4.4% | 3.7% | 4.1% | 3.6% | 4.1% | 3.5% | 2.7% | 3.9% | 2.4% | 3.6% | 3.5% | 2.8% | 2.6% | 2.7% | <0.0001 |
| Cancer of Urinary Organs | 0.9% | 0.1% | 0.1% | 0.5% | 0.4% | 0.5% | 0.3% | 0.5% | 0.5% | 0.8% | 0.1% | 0.1% | 0.4% | 0.1% | 0.4% | 0.2% | 0.2% | 0.3% | 0.5% | 0.4 |
| Diseases of the Circulatory System | 21.2% | 22.8% | 20.1% | 19.1% | 21.3% | 23.4% | 24.6% | 24.0% | 20.3% | 20.7% | 22.3% | 21.4% | 22.6% | 21.3% | 17.9% | 18.9% | 21.6% | 22.1% | 19.0% | 0.02 |
| Cardiac Diseases | 11.8% | 12.9% | 10.7% | 10.6% | 12.8% | 13.6% | 12.0% | 12.9% | 11.5% | 12.4% | 13.1% | 13.0% | 13.0% | 12.5% | 10.1% | 11.3% | 12.6% | 12.4% | 11.2% | 0.5 |
| Cerebrovascular Disease | 1.1% | 2.4% | 1.2% | 1.3% | 2.2% | 2.7% | 3.1% | 2.9% | 2.3% | 1.8% | 1.7% | 2.4% | 2.6% | 1.8% | 2.3% | 1.6% | 1.8% | 2.2% | 2.1% | 0.9 |
| Diseases of arteries and capillaries | 3.0% | 2.7% | 3.0% | 2.2% | 2.6% | 2.4% | 3.5% | 2.9% | 2.3% | 2.0% | 3.0% | 2.1% | 2.5% | 2.0% | 2.1% | 2.6% | 2.6% | 2.6% | 2.2% | 0.16 |
| Nephritis, Nephrosis, renal sclerosis | 0.9% | 0.8% | 0.9% | 0.7% | 0.8% | 0.8% | 0.4% | 0.6% | 1.2% | 1.3% | 0.8% | 0.3% | 0.4% | 0.3% | 0.3% | 0.7% | 0.4% | 0.5% | 0.3% | 0.001 |
| Acute and unspecified renal failure | 2.8% | 4.4% | 4.4% | 3.8% | 3.7% | 2.7% | 4.0% | 3.7% | 4.2% | 3.1% | 4.4% | 5.0% | 5.3% | 4.9% | 5.3% | 4.4% | 3.7% | 4.5% | 4.1% | 0.037 |
| Chronic Kidney Disease | 2.3% | 2.7% | 3.0% | 2.9% | 1.8% | 1.7% | 2.6% | 2.4% | 1.7% | 1.7% | 2.2% | 1.3% | 0.5% | 1.0% | 0.7% | 0.9% | 0.9% | 0.6% | 0.6% | <0.0001 |
| All Fatal Secondary GPA Hospitalizations | ||||||||||||||||||||
| Total Infection | 45.9% | 39.6% | 38.7% | 35.1% | 38.8% | 30.6% | 32.2% | 33.8% | 27.3% | 36.8% | 31.1% | 26.5% | 35.4% | 35.6% | 37.6% | 46.7% | 48.6% | 44.3% | 41.5% | 0.2 |
| Infectious and parasitic diseases | 10.8% | 17.0% | 9.7% | 9.1% | 16.3% | 6.5% | 3.4% | 10.8% | 8.1% | 12.6% | 5.6% | 9.6% | 24.4% | 17.3% | 20.8% | 22.8% | 27.6% | 30.0% | 25.5% | <0.0001 |
| Respiratory infection | 33.8% | 20.8% | 22.6% | 20.8% | 20.0% | 17.7% | 24.1% | 18.9% | 13.1% | 18.4% | 20.0% | 12.0% | 7.3% | 15.4% | 11.9% | 17.4% | 10.5% | 11.4% | 11.7% | <0.0001 |
| Diseases of Respiratory System (Including Infection) | 37.8% | 32.1% | 43.5% | 45.5% | 46.3% | 35.5% | 41.4% | 40.5% | 38.4% | 28.7% | 36.7% | 32.5% | 25.6% | 31.7% | 30.7% | 37.0% | 23.8% | 30.0% | 26.6% | 0.02 |
| Neoplasm | 6.8% | 7.5% | 3.2% | 9.1% | 2.5% | 6.5% | 6.9% | 4.1% | 6.1% | 5.7% | 5.6% | 9.6% | 4.9% | 4.8% | 3.0% | 2.2% | 2.9% | 2.9% | 4.3% | 0.07 |
| Cancer of Urinary Organs | 1.4% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 1.0% | 1.1% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 1.1% | 0.8 |
| Diseases of the Circulatory System | 18.9% | 22.6% | 11.3% | 14.3% | 12.5% | 21.0% | 25.3% | 24.3% | 19.2% | 26.4% | 24.4% | 20.5% | 22.0% | 22.1% | 14.9% | 14.1% | 17.1% | 17.1% | 23.4% | 0.8 |
| Cardiac Diseases | 10.8% | 11.3% | 6.5% | 11.7% | 7.5% | 8.1% | 11.5% | 10.8% | 11.1% | 16.1% | 10.0% | 13.3% | 11.0% | 12.5% | 8.9% | 6.5% | 8.6% | 11.4% | 14.9% | 0.7 |
| Cerebrovascular Disease | 4.1% | 9.4% | 0.0% | 0.0% | 1.3% | 4.8% | 4.6% | 5.4% | 4.0% | 5.7% | 5.6% | 1.2% | 3.7% | 1.9% | 1.0% | 4.3% | 5.7% | 2.9% | 3.2% | 0.9 |
| Diseases of arteries and capillaries | 0.0% | 1.9% | 1.6% | 1.3% | 1.3% | 6.5% | 6.9% | 4.1% | 3.0% | 2.3% | 5.6% | 3.6% | 2.4% | 4.8% | 2.0% | 2.2% | 2.9% | 1.4% | 0.0% | 0.8 |
| Nephritis, Nephrosis, renal sclerosis | 0.0% | 1.9% | 1.6% | 0.0% | 1.3% | 0.0% | 0.0% | 0.0% | 1.0% | 0.0% | 1.1% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 0.0% | 1.1% | 0.3 |
| Acute and unspecified renal failure | 6.8% | 0.0% | 6.5% | 3.9% | 3.8% | 1.6% | 2.3% | 4.1% | 4.0% | 3.4% | 6.7% | 8.4% | 6.1% | 4.8% | 8.9% | 7.6% | 5.7% | 7.1% | 6.4% | 0.04 |
| Chronic Kidney Disease | 2.7% | 5.7% | 0.0% | 1.3% | 1.3% | 0.0% | 0.0% | 0.0% | 1.0% | 1.1% | 1.1% | 0.0% | 0.0% | 1.0% | 0.0% | 1.1% | 0.0% | 0.0% | 0.0% | 0.006 |