Skip to main content
. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Semin Cell Dev Biol. 2016 Jul 7;61:140–149. doi: 10.1016/j.semcdb.2016.07.006

Figure 6.

Figure 6

Biomimetic ovulation in vitro via breaking apart the cortex (i.e., the alginate hydrogel shell) to release cumulus-oocyte complex (COC): (A) The effect of the combination of luteinizing hormone (LH) and epidermal growth factor (EGF) on the biomimetic ovulation, and (B) a typical image showing the ovulation of cumulus-oocyte complex (COC) from the biomimetic ovarian microtissue leaving behind a corpus luteum-like structure. N: number of antral follicles. The figure is reprinted and redrawn from reference [47] with permission from Elsevier