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. Author manuscript; available in PMC: 2018 Jun 1.
Published in final edited form as: Transplantation. 2017 Jun;101(6):1479–1487. doi: 10.1097/TP.0000000000001314

Figure 2. Increased frequency of double-cytokine and total polyfunctional CD8+ T cells in BK virus controllers versus noncontrollers after viremia start.

Figure 2

Figure 2

Figure 2

Panel A shows the frequency of BK virus-specific CD8+ T cells expressing at least two cytokines simultaneously. Panel B shows the frequency of BK virus-specific CD4+ T cells expressing at least two cytokines simultaneously. Panel C shows frequency of BK virus-specific total polyfunctional CD8+ T cells (sum of double and triple cytokine secreting cells) and total polyfunctional CD4+ T cells. Double asterisk indicates p<0.01, single asterisk indicates p<0.05. Controllers are indicated by triangles, noncontrollers by circles, and patients with low level viremia by grey squares. Panel D shows the frequency of the total population of CD8+ or CD4+ T cells secreting IFN-γ, regardless of single, double, or triple-cytokine secretion status.