Figure 1.

Example of local Z-score normalization computed for one of the subjects in the OA cohort (56-year-old male, KL 2). Arrow (A) indicates a location characterized by high values of T_1ρ in the patient map, but high heterogeneity in the control group, leading to a negligible increase of this area in the corresponding Z-score map. Arrow (B) shows a relatively homogeneous posterior lateral femur in the patient T_1ρ, corresponding with an area of low values for the controls, thus leading to higher Z-score values. OA, osteoarthritis.